Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 11/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.48 |
| ▸ | JAK3 | P52333 | 7/20 | 0.47 |
| ▸ | CDK2 | P24941 | 2/20 | 0.47 |
| ▸ | CDK1 | P06493 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | BCR | P11274 | 1/20 | 0.46 |
| ▸ | CAMK2D | Q13557 | 3/20 | 0.45 |
| ▸ | IKBKB | O14920 | 2/20 | 0.45 |
| ▸ | CHUK | O15111 | 2/20 | 0.45 |
| ▸ | IKBKG | Q9Y6K9 | 1/20 | 0.45 |
| ▸ | JAK1 | P23458 | 2/20 | 0.45 |
| ▸ | TYK2 | P29597 | 2/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
| ▸ | NCOR1 | O75376 | 1/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.45 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14021327 | 0.91 | JAK2 (0.49) | JAK2HDAC1HDAC6JAK3CDK2 | |
| SCHEMBL13911604 | 0.89 | JAK2 (0.59) | JAK2HDAC1HDAC6JAK3CDK2 | |
| SCHEMBL8313306 | 0.88 | JAK2 (0.47) | JAK2HDAC1HDAC6JAK3CDK2 | |
| SCHEMBL8313329 | 0.87 | SYK (0.53) | JAK2HDAC1HDAC6JAK3CDK2 | |
| SCHEMBL14021585 | 0.83 | CDK1 (0.53) | JAK2HDAC1HDAC6JAK3CDK2 | |
| SCHEMBL4063691 | 0.82 | JAK2 (0.52) | JAK2HDAC1HDAC6JAK3CDK2 | |
| SCHEMBL13590765 | 0.81 | JAK2 (0.51) | JAK2HDAC1HDAC6JAK3CDK2 | |
| SCHEMBL14021233 | 0.81 | CDK1 (0.49) | JAK2HDAC1HDAC6JAK3CDK2 | |
| SCHEMBL14063778 | 0.81 | JAK2 (0.51) | JAK2HDAC1HDAC6JAK3CDK2 | |
| SCHEMBL4392408 | 0.80 | PIK3CA (0.51) | JAK2HDAC1HDAC6JAK3CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004084901-A1 | METHODS FOR TREATING OR PREVENTING AN INFLAMMATORY OR METABOLIC CONDITION BY INHIBITING JNK | SIGNAL PHARMACEUTICALS, LLC (US) | 2004-10-07 | — | — | WO | disclosed |