Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 3/20 | 0.53 |
| ▸ | IKBKB | O14920 | 5/20 | 0.51 |
| ▸ | CHUK | O15111 | 5/20 | 0.51 |
| ▸ | IKBKG | Q9Y6K9 | 5/20 | 0.51 |
| ▸ | MTOR | P42345 | 1/20 | 0.50 |
| ▸ | SMG1 | Q96Q15 | 1/20 | 0.50 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 5/20 | 0.46 |
| ▸ | JAK3 | P52333 | 3/20 | 0.46 |
| ▸ | CDK1 | P06493 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 1/20 | 0.45 |
| ▸ | CAMK2D | Q13557 | 2/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
| ▸ | NCOR1 | O75376 | 1/20 | 0.45 |
| ▸ | JAK1 | P23458 | 1/20 | 0.45 |
| ▸ | TYK2 | P29597 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14063781 | 0.91 | SYK (0.53) | SYKIKBKBCHUKIKBKGMTOR | |
| SCHEMBL8313908 | 0.87 | JAK2 (0.48) | IKBKBCHUKIKBKGMTORSMG1 | |
| SCHEMBL13911604 | 0.87 | JAK2 (0.59) | SYKIKBKBCHUKIKBKGACVR1 | |
| SCHEMBL8313306 | 0.86 | JAK2 (0.47) | IKBKBCHUKIKBKGMTORSMG1 | |
| SCHEMBL8308468 | 0.84 | SYK (0.47) | SYKIKBKBCHUKIKBKGMTOR | |
| SCHEMBL8312171 | 0.84 | IKBKB (0.54) | SYKIKBKBCHUKMTORSMG1 | |
| SCHEMBL8308246 | 0.83 | SYK (0.55) | SYKSMG1ACVR1JAK2JAK3 | |
| SCHEMBL8311902 | 0.83 | IKBKB (0.50) | SYKIKBKBCHUKIKBKGMTOR | |
| SCHEMBL8311756 | 0.81 | IKBKB (0.56) | SYKIKBKBCHUKIKBKGMTOR | |
| SCHEMBL4392408 | 0.80 | PIK3CA (0.51) | IKBKBCHUKIKBKGMTORSMG1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004084901-A1 | METHODS FOR TREATING OR PREVENTING AN INFLAMMATORY OR METABOLIC CONDITION BY INHIBITING JNK | SIGNAL PHARMACEUTICALS, LLC (US) | 2004-10-07 | — | — | WO | disclosed |