Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAE1 | Q13564 | 1/20 | 0.47 |
| ▸ | UBA3 | Q8TBC4 | 1/20 | 0.47 |
| ▸ | IDO1 | P14902 | 1/20 | 0.45 |
| ▸ | KDM1A | O60341 | 3/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.44 |
| ▸ | MCHR2 | Q969V1 | 4/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12385458 | 0.89 | MCHR2 (0.50) | NAE1UBA3IDO1KDM1AHDAC1 | |
| SCHEMBL2758261 | 0.88 | KDM1A (0.46) | NAE1UBA3IDO1KDM1AHDAC1 | |
| SCHEMBL2758247 | 0.87 | KDM4E (0.50) | NAE1UBA3IDO1KDM1AHDAC1 | |
| SCHEMBL2758260 | 0.87 | NAE1 (0.46) | NAE1UBA3IDO1KDM1AHDAC1 | |
| SCHEMBL2758278 | 0.87 | NAE1 (0.44) | NAE1UBA3IDO1KDM1AHDAC1 | |
| SCHEMBL2758262 | 0.87 | HSD11B1 (0.46) | NAE1UBA3IDO1KDM1AHDAC1 | |
| SCHEMBL2758276 | 0.86 | KDM1A (0.47) | NAE1UBA3IDO1KDM1AHDAC1 | |
| SCHEMBL12084830 | 0.85 | KDM1A (0.46) | NAE1UBA3IDO1KDM1AHDAC1 | |
| SCHEMBL9089853 | 0.85 | HSD11B1 (0.46) | NAE1UBA3MCHR2HSD11B1 | |
| SCHEMBL8312069 | 0.83 | NAE1 (0.48) | NAE1UBA3IDO1KDM1AHDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0662481-B1 | Spiro piperidines and homologs promote release of growth hormone | MERCK & CO INC (US) | 1999-03-24 | — | — | EP | disclosed |
| EP-0662481-A1 | Spiro piperidines and homologs promote release of growth hormone | MERCK & CO. INC. (US) | 1995-07-12 | — | — | EP | disclosed |