Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 1/20 | 0.46 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.46 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1387799 | 1.00 | MAPK8 (0.46) | MAPK8MAPK9MAPK10 | |
| SCHEMBL1387392 | 0.82 | — | — | |
| SCHEMBL7845913 | 0.81 | PDE2A (0.45) | — | |
| SCHEMBL7845909 | 0.81 | PDE2A (0.45) | — | |
| SCHEMBL8314487 | 0.74 | PDE2A (0.50) | — | |
| SCHEMBL1387892 | 0.73 | PDE2A (0.49) | — | |
| SCHEMBL1387425 | 0.72 | PDE2A (0.48) | — | |
| SCHEMBL1387400 | 0.69 | — | — | |
| SCHEMBL921265 | 0.68 | MAPK8 (0.65) | MAPK8MAPK9MAPK10 | |
| SCHEMBL7337362 | 0.68 | PDE3B (0.51) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0708774-B1 | IMIDAZO[1,2-a]PYRAZIN-4-ONE DERIVATIVES ANTAGONISTS OF AMPA AND NMDA RECEPTORS | RHONE POULENC RORER SA (FR) | 1999-03-17 | — | — | EP | claimed |
| EP-0708774-B1 | IMIDAZO[1,2-a]PYRAZIN-4-ONE DERIVATIVES ANTAGONISTS OF AMPA AND NMDA RECEPTORS | RHONE POULENC RORER SA (FR) | 1999-03-17 | — | — | EP | disclosed |