Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 16/20 | 0.55 |
| ▸ | EGFR | P00533 | 2/20 | 0.54 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8317678 | 0.86 | EGFR (0.58) | BRAFEGFRERBB2HPGDHTT | |
| SCHEMBL8316261 | 0.84 | EGFR (0.68) | BRAFEGFRERBB2HPGDHTT | |
| SCHEMBL8317972 | 0.83 | BRAF (0.59) | BRAFEGFRERBB2HPGDHTT | |
| SCHEMBL8318808 | 0.82 | EGFR (0.55) | BRAFEGFRERBB2HPGDHTT | |
| SCHEMBL8314918 | 0.82 | EGFR (0.55) | BRAFEGFRERBB2HPGDHTT | |
| SCHEMBL8319491 | 0.82 | BRAF (0.54) | BRAFEGFRERBB2HPGDHTT | |
| SCHEMBL8315188 | 0.81 | BRAF (0.66) | BRAFEGFRERBB2HPGDHTT | |
| SCHEMBL8315628 | 0.81 | BRAF (0.60) | BRAFEGFRERBB2HPGDHTT | |
| SCHEMBL8314154 | 0.80 | BRAF (0.56) | BRAFEGFRERBB2HPGDHTT | |
| SCHEMBL8319410 | 0.79 | EGFR (0.57) | BRAFEGFRERBB2HPGDHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0779888-B1 | PYRIMIDO [5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | BOEHRINGER INGELHEIM PHARMA (DE) | 1999-04-28 | — | — | EP | disclosed |