Sugi Predict

Sugi Predict / Compounds / SCHEMBL8319491

SCHEMBL8319491

SCHEMBL8319491

Cc1cccc(Nc2ncnc3cnc(NC4CC4)nc23)c1F

nearest known ligand 0.54

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
▸ BRAF P15056 13/20 0.54
▸ EGFR P00533 4/20 0.51
▸ ERBB2 P04626 1/20 0.51
▸ HPGD P15428 1/20 0.51
▸ HTT P42858 1/20 0.51
▸ KHK P50053 1/20 0.42
▸ CDK7 P50613 2/20 0.42
▸ CDK9 P50750 2/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8315628 0.89 BRAF (0.60) BRAFEGFRERBB2HPGDHTT
SCHEMBL8318808 0.85 EGFR (0.55) BRAFEGFRERBB2HPGDHTT
SCHEMBL8316719 0.85 EGFR (0.50) BRAFEGFRERBB2HPGDHTT
SCHEMBL8314918 0.85 EGFR (0.55) BRAFEGFRERBB2HPGDHTT
SCHEMBL8314440 0.82 BRAF (0.55) BRAFEGFRERBB2HPGDHTT
SCHEMBL8317678 0.81 EGFR (0.58) BRAFEGFRERBB2HPGDHTT
SCHEMBL8315188 0.81 BRAF (0.66) BRAFEGFRERBB2HPGDHTT
SCHEMBL8316261 0.79 EGFR (0.68) BRAFEGFRERBB2HPGDHTT
SCHEMBL8317972 0.78 BRAF (0.59) BRAFEGFRERBB2HPGDHTT
SCHEMBL8317928 0.78 EGFR (0.60) BRAFEGFRERBB2HPGDHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0779888-B1 PYRIMIDO [5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM BOEHRINGER INGELHEIM PHARMA (DE) 1999-04-28 — — EP disclosed