Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 11/20 | 0.60 |
| ▸ | KHK | P50053 | 2/20 | 0.52 |
| ▸ | EGFR | P00533 | 3/20 | 0.50 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | CDK7 | P50613 | 2/20 | 0.47 |
| ▸ | CDK9 | P50750 | 2/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.46 |
| ▸ | AXL | P30530 | 1/20 | 0.45 |
| ▸ | MERTK | Q12866 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8319491 | 0.89 | BRAF (0.54) | BRAFKHKEGFRERBB2HPGD | |
| SCHEMBL8318808 | 0.87 | EGFR (0.55) | BRAFEGFRERBB2HPGDHTT | |
| SCHEMBL8315188 | 0.86 | BRAF (0.66) | BRAFEGFRERBB2HPGDHTT | |
| SCHEMBL8319961 | 0.81 | EGFR (0.58) | BRAFEGFRERBB2HPGDHTT | |
| SCHEMBL8314440 | 0.81 | BRAF (0.55) | BRAFEGFRERBB2HPGDHTT | |
| SCHEMBL8317471 | 0.81 | EGFR (0.61) | BRAFEGFRERBB2HPGDHTT | |
| SCHEMBL8314918 | 0.80 | EGFR (0.55) | BRAFEGFRERBB2HPGDHTT | |
| SCHEMBL8317678 | 0.80 | EGFR (0.58) | BRAFEGFRERBB2HPGDHTT | |
| SCHEMBL8319410 | 0.80 | EGFR (0.57) | BRAFEGFRERBB2HPGDHTT | |
| SCHEMBL8319428 | 0.80 | EGFR (0.73) | BRAFEGFRERBB2HPGDHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0779888-B1 | PYRIMIDO [5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | BOEHRINGER INGELHEIM PHARMA (DE) | 1999-04-28 | — | — | EP | disclosed |
| EP-0779888-A1 | PYRIMIDO [5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | Dr. Karl Thomae GmbH (DE) | 1997-06-25 | — | — | EP | disclosed |
| WO-1996007657-A1 | PYRIMIDO[5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | DR. KARL THOMAE GMBH (DE) | 1996-03-14 | — | — | WO | disclosed |