Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 12/20 | 0.51 |
| ▸ | CHUK | O15111 | 12/20 | 0.51 |
| ▸ | IKBKG | Q9Y6K9 | 1/20 | 0.49 |
| ▸ | MKNK1 | Q9BUB5 | 4/20 | 0.48 |
| ▸ | MKNK2 | Q9HBH9 | 5/20 | 0.46 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.46 |
| ▸ | CCNC | P24863 | 1/20 | 0.44 |
| ▸ | CDK8 | P49336 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8165798 | 0.97 | IKBKB (0.51) | IKBKBCHUKIKBKGMKNK1MKNK2 | |
| SCHEMBL14063856 | 0.94 | IKBKB (0.53) | IKBKBCHUKMKNK1MKNK2DYRK2 | |
| SCHEMBL8313335 | 0.90 | IKBKB (0.49) | IKBKBCHUKIKBKG | |
| SCHEMBL8308363 | 0.88 | IKBKB (0.50) | IKBKBCHUKIKBKGMKNK1MKNK2 | |
| SCHEMBL8312555 | 0.87 | IKBKB (0.52) | IKBKBCHUKIKBKGMKNK1MKNK2 | |
| SCHEMBL5070979 | 0.87 | IKBKB (0.47) | IKBKBCHUKIKBKG | |
| SCHEMBL4070513 | 0.86 | IKBKB (0.48) | IKBKBCHUKIKBKG | |
| SCHEMBL8315467 | 0.85 | IKBKB (0.52) | IKBKBCHUKIKBKGMKNK1MKNK2 | |
| SCHEMBL8313394 | 0.83 | IKBKB (0.46) | IKBKBCHUKIKBKGDYRK2 | |
| SCHEMBL4066231 | 0.83 | CAMK2D (0.63) | IKBKBCHUKIKBKG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7442699-B2 | Anilinopyrimidine derivatives as IKK inhibitors and compositions and methods related thereto | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-10-28 | — | — | US | disclosed |
| US-7442699-B2 | Anilinopyrimidine derivatives as IKK inhibitors and compositions and methods related thereto | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-10-28 | — | — | US | disclosed |
| US-7429599-B2 | Methods for treating or preventing an inflammatory or metabolic condition or inhibiting JNK | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-09-30 | — | — | US | disclosed |
| US-7429599-B2 | Methods for treating or preventing an inflammatory or metabolic condition or inhibiting JNK | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-09-30 | — | — | US | disclosed |
| WO-2004084901-A1 | METHODS FOR TREATING OR PREVENTING AN INFLAMMATORY OR METABOLIC CONDITION BY INHIBITING JNK | SIGNAL PHARMACEUTICALS, LLC (US) | 2004-10-07 | — | — | WO | disclosed |