Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 19/20 | 0.63 |
| ▸ | CHUK | O15111 | 16/20 | 0.63 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.53 |
| ▸ | CDK2 | P24941 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8314580 | 0.93 | IKBKB (0.66) | IKBKBCHUK | |
| SCHEMBL8311727 | 0.92 | IKBKB (0.63) | IKBKBCHUK | |
| SCHEMBL8313918 | 0.92 | IKBKB (0.65) | IKBKBCHUK | |
| SCHEMBL8312299 | 0.88 | IKBKB (0.72) | IKBKBCHUK | |
| SCHEMBL8312297 | 0.87 | IKBKB (0.64) | IKBKBCHUKCCNE1CDK2 | |
| SCHEMBL8308557 | 0.86 | IKBKB (0.59) | IKBKBCHUKCCNE1CDK2 | |
| SCHEMBL8309279 | 0.85 | IKBKB (0.59) | IKBKBCHUKCCNE1CDK2 | |
| SCHEMBL8308491 | 0.85 | IKBKB (0.57) | IKBKBCHUKCCNE1CDK2 | |
| SCHEMBL8312855 | 0.85 | IKBKB (0.59) | IKBKBCHUKCCNE1CDK2 | |
| SCHEMBL27634134 | 0.84 | IKBKB (0.67) | IKBKBCHUKCCNE1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7429599-B2 | Methods for treating or preventing an inflammatory or metabolic condition or inhibiting JNK | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-09-30 | — | — | US | disclosed |
| US-7429599-B2 | Methods for treating or preventing an inflammatory or metabolic condition or inhibiting JNK | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-09-30 | — | — | US | disclosed |
| WO-2004084901-A1 | METHODS FOR TREATING OR PREVENTING AN INFLAMMATORY OR METABOLIC CONDITION BY INHIBITING JNK | SIGNAL PHARMACEUTICALS, LLC (US) | 2004-10-07 | — | — | WO | disclosed |