Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | TYR | P14679 | 1/20 | 0.41 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.40 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.40 |
| ▸ | CDK2 | P24941 | 2/20 | 0.40 |
| ▸ | AHR | P35869 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11855787 | 0.84 | ACHE (0.55) | NPC1RAB9AMAOAALDH1A1KDM4E | |
| SCHEMBL11756028 | 0.78 | HDAC1 (0.41) | — | |
| SCHEMBL8099246 | 0.75 | ACHE (0.45) | RAB9AALDH1A1KDM4EHPGDGAA | |
| SCHEMBL8560121 | 0.73 | ACHE (0.66) | ALDH1A1TYRPOLB | |
| SCHEMBL30666419 | 0.73 | ACHE (0.40) | RAB9AMAPT | |
| SCHEMBL8558933 | 0.73 | ACHE (0.40) | RAB9AMAPT | |
| SCHEMBL4814588 | 0.72 | NPC1 (0.56) | NPC1RAB9AMAOAALDH1A1KDM4E | |
| SCHEMBL28048491 | 0.72 | ADRA2A (0.51) | NPC1RAB9AMAOAALDH1A1KDM4E | |
| SCHEMBL9379650 | 0.71 | NPC1 (0.55) | NPC1RAB9AMAOAALDH1A1KDM4E | |
| SCHEMBL8555103 | 0.71 | PIM1 (0.46) | NPC1ALDH1A1KDM4EGAATYR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0752991-B1 | IMIDAZO[1,2-a]INDENO[1,2-e]PYRAZIN-4-ONES ANTAGONISTS OF AMPA AND NMDA RECEPTORS | RHONE POULENC RORER SA (FR) | 1999-05-26 | — | — | EP | disclosed |
| US-5789406-A | Indeno 1,2-E!pyrazine-4-ones, their preparation and the medicaments containing them | RHONE-POULENC RORER S.A. (FR) | 1998-08-04 | — | — | US | disclosed |
| EP-0752991-A1 | INDENO[1,2-e]PYRAZINE-4-ONES, PREPARATION THEREOF AND DRUGS CONTAINING SAME | Aventis Pharma S.A. (FR) | 1997-01-15 | — | — | EP | disclosed |
| WO-1995026349-A1 | INDENO[1,2-e]PYRAZINE-4-ONES, PREPARATION THEREOF AND DRUGS CONTAINING SAME | RHONE-POULENC RORER S.A. (FR) | 1995-10-05 | — | — | WO | disclosed |