Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 8/20 | 0.49 |
| ▸ | RXRB | P28702 | 7/20 | 0.49 |
| ▸ | RXRG | P48443 | 5/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | NR4A2 | P43354 | 3/20 | 0.47 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.47 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.47 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.44 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.44 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.44 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.44 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.44 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5370663 | 0.89 | ALDH1A1 (0.43) | HPGDALDH1A1NPC1RAB9A | |
| SCHEMBL8310205 | 0.74 | ALDH1A1 (0.50) | HPGDALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL27576865 | 0.74 | ALDH1A1 (0.44) | ALDH1A1NPC1POLBRAB9ASMN1; SMN2 | |
| SCHEMBL11953861 | 0.73 | ALDH1A1 (0.51) | RXRARXRBRXRGHPGDNR4A2 | |
| SCHEMBL11133454 | 0.73 | HTT (0.45) | ALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL27832128 | 0.71 | NR4A1 (0.67) | RXRARXRBRXRGHPGDNR4A2 | |
| SCHEMBL1287366 | 0.70 | SMN1; SMN2 (0.41) | ALDH1A1NPC1POLBRAB9ASMN1; SMN2 | |
| SCHEMBL7587208 | 0.70 | ALDH1A1 (0.47) | NR4A2NR4A1NR4A3ALDH1A1NPC1 | |
| SCHEMBL5089520 | 0.70 | ALDH1A1 (0.42) | HPGDALDH1A1NPC1POLBRAB9A | |
| SCHEMBL8021970 | 0.70 | ALDH1A1 (0.42) | HPGDALDH1A1NPC1POLBRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934262-A1 | BETA-THIOPROPIONYL-AMINO ACID DERIVATIVES AND THEIR USE AS BETA-LACTAMASE INHIBITORS | SMITHKLINE BEECHAM PLC (GB) | 1999-08-11 | — | — | EP | disclosed |
| WO-1998017639-A1 | BETA-THIOPROPIONYL-AMINO ACID DERIVATIVES AND THEIR USE AS BETA-LACTAMASE INHIBITORS | SMITHKLINE BEECHAM PLC (GB) | 1998-04-30 | — | — | WO | disclosed |