Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 5/20 | 0.58 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | CSNK2A1 | P68400 | 3/20 | 0.54 |
| ▸ | BRAF | P15056 | 4/20 | 0.48 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.45 |
| ▸ | CSNK2B | P67870 | 2/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | CTSV | O60911 | 1/20 | 0.41 |
| ▸ | PLAT | P00750 | 1/20 | 0.41 |
| ▸ | CTSL | P07711 | 1/20 | 0.41 |
| ▸ | CTSB | P07858 | 1/20 | 0.41 |
| ▸ | CTSH | P09668 | 1/20 | 0.41 |
| ▸ | CTSS | P25774 | 1/20 | 0.41 |
| ▸ | CASP14 | P31944 | 1/20 | 0.41 |
| ▸ | CTSK | P43235 | 1/20 | 0.41 |
| ▸ | CASP4 | P49662 | 1/20 | 0.41 |
| ▸ | CASP5 | P51878 | 1/20 | 0.41 |
| ▸ | CASP6 | P55212 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8317928 | 0.89 | EGFR (0.60) | EGFRERBB2HPGDHTTCSNK2A1 | |
| SCHEMBL8315463 | 0.88 | EGFR (0.61) | EGFRERBB2HPGDHTTCSNK2A1 | |
| SCHEMBL8319410 | 0.86 | EGFR (0.57) | EGFRERBB2HPGDHTTCSNK2A1 | |
| SCHEMBL8317453 | 0.85 | EGFR (0.69) | EGFRERBB2HPGDHTTCSNK2A1 | |
| SCHEMBL8317815 | 0.85 | EGFR (0.53) | EGFRERBB2HPGDHTTCSNK2A1 | |
| SCHEMBL8320277 | 0.84 | CSNK2A1 (0.56) | EGFRERBB2HPGDHTTCSNK2A1 | |
| SCHEMBL8320282 | 0.84 | CSNK2A1 (0.56) | EGFRERBB2HPGDHTTCSNK2A1 | |
| SCHEMBL8316261 | 0.82 | EGFR (0.68) | EGFRERBB2HPGDHTTCSNK2A1 | |
| SCHEMBL8314263 | 0.82 | EGFR (0.84) | EGFRERBB2HPGDHTTCSNK2A1 | |
| SCHEMBL8317972 | 0.81 | BRAF (0.59) | EGFRERBB2HPGDHTTCSNK2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0779888-B1 | PYRIMIDO [5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | BOEHRINGER INGELHEIM PHARMA (DE) | 1999-04-28 | — | — | EP | disclosed |