Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 4/20 | 0.53 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.47 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.47 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.47 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.47 |
| ▸ | CTSC | P53634 | 1/20 | 0.47 |
| ▸ | BRAF | P15056 | 4/20 | 0.46 |
| ▸ | ULK1 | O75385 | 5/20 | 0.43 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.43 |
| ▸ | AXL | P30530 | 1/20 | 0.42 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.42 |
| ▸ | MERTK | Q12866 | 1/20 | 0.42 |
| ▸ | ULK2 | Q8IYT8 | 1/20 | 0.42 |
| ▸ | PAK1 | Q13153 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8318987 | 0.89 | CTSC (0.61) | EGFRERBB2HPGDHTTCSNK2A1 | |
| SCHEMBL8314951 | 0.85 | EGFR (0.58) | EGFRERBB2HPGDHTTCSNK2A1 | |
| SCHEMBL8319410 | 0.83 | EGFR (0.57) | EGFRERBB2HPGDHTTCSNK2A1 | |
| SCHEMBL8314154 | 0.82 | BRAF (0.56) | EGFRERBB2HPGDHTTCSNK2A1 | |
| SCHEMBL8316151 | 0.82 | EGFR (0.64) | EGFRERBB2HPGDHTTBRAF | |
| SCHEMBL8315463 | 0.80 | EGFR (0.61) | EGFRERBB2HPGDHTTCSNK2A1 | |
| SCHEMBL8315669 | 0.80 | EGFR (0.56) | EGFRERBB2HPGDHTTBRAF | |
| SCHEMBL8317453 | 0.80 | EGFR (0.69) | EGFRERBB2HPGDHTTCSNK2A1 | |
| SCHEMBL8317928 | 0.79 | EGFR (0.60) | EGFRERBB2HPGDHTTCSNK2A1 | |
| SCHEMBL8314012 | 0.78 | SYK (0.53) | EGFRERBB2HPGDHTTCSNK2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0779888-B1 | PYRIMIDO [5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | BOEHRINGER INGELHEIM PHARMA (DE) | 1999-04-28 | — | — | EP | disclosed |