Sugi Predict

Sugi Predict / Compounds / SCHEMBL8315320

SCHEMBL8315320

SCHEMBL8315320

CC(C)(C)OC(=O)NC(C)(C)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)CC(NS(=O)(=O)c1ccccc1)c1ccccc12

nearest known ligand 0.57

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
▸ GHSR Q92847 1/20 0.51
▸ TACR1 P25103 18/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8315316 1.00 GHSR (0.51) GHSRTACR1
SCHEMBL8311100 0.89 GHSR (0.64) GHSRTACR1
SCHEMBL8311105 0.89 GHSR (0.64) GHSRTACR1
SCHEMBL8314876 0.88 GHSR (0.49) GHSRTACR1
SCHEMBL8314871 0.88 GHSR (0.49) GHSRTACR1
Hydrochloric Acid SCHEMBL8313088 0.88 GHSR (0.63) GHSRTACR1
Hydrochloric Acid SCHEMBL8313093 0.88 GHSR (0.63) GHSRTACR1
SCHEMBL8311164 0.87 GHSR (0.53) GHSRTACR1
SCHEMBL8311168 0.87 GHSR (0.53) GHSRTACR1
SCHEMBL8311930 0.84 MEN1 (0.46) TACR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0662481-B1 Spiro piperidines and homologs promote release of growth hormone MERCK & CO INC (US) 1999-03-24 — — EP disclosed
US-5578593-A RELEASING GROWTH HORMONES FOR ANIMALS MERCK & CO., INC. (US) 1996-11-26 — — US disclosed
EP-0662481-A1 Spiro piperidines and homologs promote release of growth hormone MERCK & CO. INC. (US) 1995-07-12 — — EP disclosed