Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GHSR | Q92847 | 2/20 | 0.53 |
| ▸ | TACR1 | P25103 | 12/20 | 0.44 |
| ▸ | PPARA | Q07869 | 1/20 | 0.42 |
| ▸ | KLK7 | P49862 | 1/20 | 0.41 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.41 |
| ▸ | CTSS | P25774 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | UGCG | Q16739 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8311164 | 1.00 | GHSR (0.53) | GHSRTACR1PPARAKLK7KLK5 | |
| SCHEMBL8314876 | 0.88 | GHSR (0.49) | GHSRTACR1PPARAKLK7KLK5 | |
| SCHEMBL8314871 | 0.88 | GHSR (0.49) | GHSRTACR1PPARAKLK7KLK5 | |
| SCHEMBL8315316 | 0.87 | GHSR (0.51) | GHSRTACR1 | |
| SCHEMBL8315320 | 0.87 | GHSR (0.51) | GHSRTACR1 | |
| SCHEMBL7572185 | 0.83 | GHSR (0.52) | GHSRTACR1PPARACTSSCYP3A4 | |
| SCHEMBL8311537 | 0.81 | MEN1 (0.48) | TACR1CTSSCYP3A4UGCG | |
| SCHEMBL8311541 | 0.81 | MEN1 (0.48) | TACR1CTSSCYP3A4UGCG | |
| SCHEMBL30661940 | 0.81 | GHSR (0.78) | GHSRTACR1 | |
| SCHEMBL7567562 | 0.81 | GHSR (0.59) | GHSRTACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0662481-B1 | Spiro piperidines and homologs promote release of growth hormone | MERCK & CO INC (US) | 1999-03-24 | — | — | EP | disclosed |
| US-5578593-A | RELEASING GROWTH HORMONES FOR ANIMALS | MERCK & CO., INC. (US) | 1996-11-26 | — | — | US | disclosed |
| EP-0662481-A1 | Spiro piperidines and homologs promote release of growth hormone | MERCK & CO. INC. (US) | 1995-07-12 | — | — | EP | disclosed |