Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | DAO | P14920 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4424865 | 0.76 | CYP1A2 (0.36) | ALDH1A1GLAHPGD | |
| SCHEMBL4420694 | 0.68 | SLC9A1 (0.37) | KDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL8451107 | 0.62 | ALDH1A1 (0.35) | KDM4EALDH1A1GLAHPGD | |
| SCHEMBL17511896 | 0.59 | PI4KA (0.43) | KDM4EALDH1A1GLAHPGDSMN1; SMN2 | |
| SCHEMBL856888 | 0.58 | — | — | |
| SCHEMBL199450 | 0.58 | LCK (0.41) | KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL15404712 | 0.56 | ENPP1 (0.43) | — | |
| SCHEMBL858732 | 0.56 | ALDH1A1 (0.37) | KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL6770705 | 0.55 | — | — | |
| SCHEMBL11383178 | 0.55 | ALDH1A1 (1.00) | KDM4EALDH1A1GLAHPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0635507-B1 | Tricyclic derivatives and their use as anti-cancer agents | ZENECA LTD (GB) | 1999-09-15 | — | — | EP | claimed |
| US-5569658-A | Tricyclic derivatives | ZENECA LIMITED (GB) | 1996-10-29 | — | — | US | claimed |
| EP-0635507-A1 | Tricyclic derivatives and their use as anti-cancer agents | ZENECA LIMITED (GB) | 1995-01-25 | — | — | EP | claimed |
| EP-0635507-B1 | Tricyclic derivatives and their use as anti-cancer agents | ZENECA LTD (GB) | 1999-09-15 | — | — | EP | disclosed |
| US-5569658-A | Tricyclic derivatives | ZENECA LIMITED (GB) | 1996-10-29 | — | — | US | disclosed |
| EP-0635507-A1 | Tricyclic derivatives and their use as anti-cancer agents | ZENECA LIMITED (GB) | 1995-01-25 | — | — | EP | disclosed |