Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 5/20 | 0.54 |
| ▸ | HTR2C | P28335 | 4/20 | 0.54 |
| ▸ | HTR7 | P34969 | 4/20 | 0.54 |
| ▸ | HTR6 | P50406 | 4/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.47 |
| ▸ | MGLL | Q99685 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8315456 | 0.83 | HTR2A (0.56) | HTR2AHTR2CHTR7HTR6KCNH2 | |
| SCHEMBL1583112 | 0.74 | HTR2A (0.76) | HTR2AHTR2CHTR7HTR6KCNH2 | |
| SCHEMBL9289676 | 0.73 | KDM4E (0.53) | HTR2AHTR2CHTR7HTR6KDM4E | |
| SCHEMBL11708162 | 0.73 | HTR2A (0.64) | HTR2AHTR2CHTR7HTR6KCNH2 | |
| SCHEMBL9118514 | 0.73 | HTR2A (0.53) | HTR2AHTR2CHTR7HTR6KDM4E | |
| SCHEMBL14318600 | 0.73 | HTR2A (0.81) | HTR2AHTR2CHTR7HTR6KDM4E | |
| Milenperone SCHEMBL29710910 | 0.72 | CYP2D6 (0.58) | HTR2AHTR2CHTR7HTR6KCNH2 | |
| Milenperone SCHEMBL121986 | 0.72 | CYP2D6 (0.58) | HTR2AHTR2CHTR7HTR6KCNH2 | |
| SCHEMBL1582719 | 0.71 | KCNH2 (0.83) | HTR2AHTR2CHTR7HTR6KCNH2 | |
| SCHEMBL11708317 | 0.71 | HTR2A (0.64) | HTR2AHTR2CHTR7HTR6KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0850235-B1 | QUINOLEIN-2(1H)-ONE DERIVATIVES AS SEROTONIN ANTAGONISTS | SANOFI SYNTHELABO (FR) | 1999-12-01 | — | — | EP | claimed |
| EP-0850235-B1 | QUINOLEIN-2(1H)-ONE DERIVATIVES AS SEROTONIN ANTAGONISTS | SANOFI SYNTHELABO (FR) | 1999-12-01 | — | — | EP | disclosed |