⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29191177 | 0.78 | NPC1 (0.42) | — | |
| SCHEMBL41049 | 0.72 | — | — | |
| SCHEMBL29581302 | 0.72 | — | — | |
| SCHEMBL687504 | 0.72 | PSMD14 (0.52) | — | |
| SCHEMBL27892006 | 0.72 | LMNA (0.48) | — | |
| SCHEMBL29361780 | 0.72 | — | — | |
| SCHEMBL2697704 | 0.72 | — | — | |
| Chloroform SCHEMBL27952669 | 0.72 | LMNA (0.43) | — | |
| SCHEMBL29398460 | 0.70 | — | — | |
| SCHEMBL31147201 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119264533-A | Low-temperature-resistant rare earth butadiene rubber and preparation method thereof | 山东产研中科高端化工产业技术研究院有限公司 | 2025-01-07 | — | — | CN | claimed |
| CN-119264533-A | Low-temperature-resistant rare earth butadiene rubber and preparation method thereof | 山东产研中科高端化工产业技术研究院有限公司 | 2025-01-07 | — | — | CN | disclosed |
| EP-3753941-B1 | PYRIMIDINE-FUSED CYCLIC COMPOUND, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | SHANGHAI BLUERAY BIOPHARMA CO LTD (CN) | 2024-05-01 | — | — | EP | disclosed |
| US-20230234958-A1 | SHP2 PHOSPHATASE INHIBITORS AND METHODS OF USE THEREOF | D. E. SHAW RESEARCH, LLC | 2023-07-27 | — | — | US | disclosed |
| US-11498930-B2 | Pyrimidine-fused cyclic compound, preparation method therefor and application thereof | Blueray Therapeutics (Shanghai) Co., Ltd (CN) | 2022-11-15 | — | — | US | disclosed |
| US-11498930-B2 | Pyrimidine-fused cyclic compound, preparation method therefor and application thereof | Blueray Therapeutics (Shanghai) Co., Ltd (CN) | 2022-11-15 | — | — | US | disclosed |
| WO-2022135430-A1 | HETEROARYL COMPOUNDS, PREPARATION METHODS AND USES THEREOF | InventisBio Co., Ltd. (CN) | 2022-06-30 | — | — | WO | disclosed |
| US-20210053989-A1 | PYRIMIDINE-FUSED CYCLIC COMPOUND, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | SHANGHAI BLUERAY BIOPHARMA CO., LTD. (CN) | 2021-02-25 | — | — | US | disclosed |
| US-20210053989-A1 | PYRIMIDINE-FUSED CYCLIC COMPOUND, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | SHANGHAI BLUERAY BIOPHARMA CO., LTD. (CN) | 2021-02-25 | — | — | US | disclosed |
| EP-3753941-A1 | PYRIMIDINE-FUSED CYCLIC COMPOUND, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | Shanghai Blueray Biopharma Co., Ltd. (CN) | 2020-12-23 | — | — | EP | disclosed |
| WO-2016203406-A1 | COMPOUNDS AND COMPOSITIONS FOR INHIBITING THE ACTIVITY OF SHP2 | NOVARTIS AG (CH) | 2016-12-22 | — | — | WO | disclosed |
| WO-2016203405-A1 | COMPOUNDS AND COMPOSITIONS FOR INHIBITING THE ACTIVITY OF SHP2 | NOVARTIS AG (CH) | 2016-12-22 | — | — | WO | disclosed |
| US-9249160-B2 | Orexin receptor antagonists | HEPTARES THERAPEUTICS LIMITED (GB) | 2016-02-02 | — | — | US | disclosed |
| WO-2015107494-A1 | 1 -(TRIAZIN-3-YI_/PYRIDAZIN-3-YL)-PIPER(-AZINE)IDINE DERIVATIVES AND COMPOSITIONS THEREOF FOR INHIBITING THE ACTIVITY OF SHP2 | NOVARTIS AG (CH) | 2015-07-23 | — | — | WO | disclosed |
| US-20150126498-A1 | OREXIN RECEPTOR ANTAGONISTS | NXERA PHARMA UK LIMITED (GB) | 2015-05-07 | — | — | US | disclosed |
| EP-0611757-B1 | Process for the preparation of azaphenothiazines | ASTA MEDICA AG (DE) | 1999-01-20 | — | — | EP | disclosed |
| US-5539107-A | REACTION OF CHLOROPYRIDINE AND CHLOROQUINOLINES WITH MERCAPTOANILINES OR BIS/O-AMINOPHENYL DISULFIDE | ASTA MEDICA AKTIENGESELLSCHAFT (DE) | 1996-07-23 | — | — | US | disclosed |
| US-5446148-A | Chemical intermediates for making antitussive agent, antihistamines and antipsychotic agent; efficiency, by-product inhibition | ASTA MEDICA AKTIENGESELLSCHAFT (DE) | 1995-08-29 | — | — | US | disclosed |
| EP-0611757-A1 | Process for the preparation of azaphenothiazines | ASTA Medica Aktiengesellschaft (DE) | 1994-08-24 | — | — | EP | disclosed |
| US-4148899-A | BACTERICIDES, FUNGICIDES | THE DOW CHEMICAL COMPANY (US) | 1979-04-10 | — | — | US | disclosed |