Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | CETP | P11597 | 1/20 | 0.31 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.31 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.31 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.31 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.31 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.31 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.31 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8654847 | 0.87 | GRIN2D (0.35) | CYP19A1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL28827150 | 0.84 | SIRT2 (0.40) | CYP19A1CETP | |
| SCHEMBL1254598 | 0.81 | MAPT (0.31) | CYP19A1TSHR | |
| SCHEMBL21121157 | 0.74 | — | — | |
| SCHEMBL4564982 | 0.70 | CYP19A1 (0.39) | CYP19A1 | |
| SCHEMBL28240742 | 0.70 | MEN1 (0.33) | LMNATSHR | |
| SCHEMBL25176544 | 0.69 | CYP2C19 (0.37) | CYP19A1LMNATSHR | |
| SCHEMBL4605079 | 0.68 | GRIN1 (0.38) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL8978123 | 0.68 | CETP (0.32) | CETPLMNATSHR | |
| SCHEMBL1082424 | 0.68 | CETP (0.33) | CETPGRIN2DGRIN3BGRIN1GRIN2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0923552-A1 | PYRANOINDOLE AND CARBAZOLE INHIBITORS OF COX-2 | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-06-23 | — | — | EP | disclosed |
| WO-1998004527-A1 | PYRANOINDOLE AND CARBAZOLE INHIBITORS OF COX-2 | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-02-05 | — | — | WO | disclosed |