Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 17/20 | 0.58 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.57 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.57 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.57 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.52 |
| ▸ | CDK1 | P06493 | 2/20 | 0.52 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.52 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.52 |
| ▸ | FADS1 | O60427 | 1/20 | 0.51 |
| ▸ | LCK | P06239 | 1/20 | 0.50 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8313472 | 0.88 | EGFR (0.53) | EGFRCSNK2A2CSNK2BCSNK2A1CCNB2 | |
| SCHEMBL8318451 | 0.87 | EGFR (0.77) | EGFR | |
| SCHEMBL8317099 | 0.86 | EGFR (0.77) | EGFR | |
| SCHEMBL8315646 | 0.86 | EGFR (0.58) | EGFRLCK | |
| SCHEMBL8314176 | 0.86 | EGFR (0.53) | EGFRCSNK2A2CSNK2BCSNK2A1FADS1 | |
| SCHEMBL8314039 | 0.85 | EGFR (0.52) | EGFRCSNK2A2CSNK2BCSNK2A1ERBB2 | |
| SCHEMBL6993701 | 0.84 | EGFR (0.64) | EGFRERBB2 | |
| SCHEMBL8316788 | 0.84 | EGFR (0.58) | EGFRFADS1LCKERBB2 | |
| SCHEMBL8318849 | 0.84 | EGFR (0.55) | EGFRCSNK2A1LCKERBB2 | |
| SCHEMBL8314074 | 0.82 | ABCG2 (0.55) | EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0779888-B1 | PYRIMIDO [5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | BOEHRINGER INGELHEIM PHARMA (DE) | 1999-04-28 | — | — | EP | disclosed |