Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 17/20 | 0.58 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.53 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.51 |
| ▸ | LCK | P06239 | 1/20 | 0.47 |
| ▸ | FBP1 | P09467 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8318451 | 0.87 | EGFR (0.77) | EGFR | |
| SCHEMBL8315864 | 0.86 | EGFR (0.58) | EGFRLCK | |
| SCHEMBL8317099 | 0.86 | EGFR (0.77) | EGFR | |
| SCHEMBL8318849 | 0.84 | EGFR (0.55) | EGFRABCG2LCKFBP1 | |
| SCHEMBL6993701 | 0.82 | EGFR (0.64) | EGFRFBP1 | |
| SCHEMBL8314074 | 0.82 | ABCG2 (0.55) | EGFRABCG2 | |
| SCHEMBL8317928 | 0.81 | EGFR (0.60) | EGFRMAP4K4ABCG2 | |
| SCHEMBL8314039 | 0.81 | EGFR (0.52) | EGFR | |
| SCHEMBL8314880 | 0.80 | EGFR (0.53) | EGFRABCG2LCKFBP1 | |
| SCHEMBL8314131 | 0.79 | EGFR (0.53) | EGFRABCG2LCKFBP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0779888-B1 | PYRIMIDO [5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | BOEHRINGER INGELHEIM PHARMA (DE) | 1999-04-28 | — | — | EP | disclosed |
| EP-0779888-A1 | PYRIMIDO [5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | Dr. Karl Thomae GmbH (DE) | 1997-06-25 | — | — | EP | disclosed |
| WO-1996007657-A1 | PYRIMIDO[5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | DR. KARL THOMAE GMBH (DE) | 1996-03-14 | — | — | WO | disclosed |