Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 9/20 | 0.34 |
| ▸ | RAB9A | P51151 | 9/20 | 0.34 |
| ▸ | MAPT | P10636 | 9/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.34 |
| ▸ | MEN1 | O00255 | 6/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.34 |
| ▸ | LMNA | P02545 | 4/20 | 0.34 |
| ▸ | HPGD | P15428 | 4/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.34 |
| ▸ | CASP3 | P42574 | 1/20 | 0.34 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.34 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.34 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | SULT1A1 | P50225 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.33 |
| ▸ | TAS2R38 | P59533 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8317268 | 0.83 | APP (0.42) | MAPTKMT2AMEN1SULT1A1GAA | |
| SCHEMBL8315862 | 0.79 | ALOX5 (0.44) | NPC1RAB9AMAPTSMN1; SMN2KDM4E | |
| Hydrochloric Acid SCHEMBL8315893 | 0.78 | MAPT (0.38) | NPC1RAB9AMAPTSMN1; SMN2KDM4E | |
| SCHEMBL8316989 | 0.77 | PTGDR2 (0.38) | NPC1RAB9AKMT2ASMN1; SMN2KDM4E | |
| SCHEMBL8312319 | 0.76 | NPC1 (0.37) | NPC1RAB9AKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL8310827 | 0.76 | PIK3CD (0.40) | NPC1RAB9AMAPTKMT2AMEN1 | |
| SCHEMBL8315777 | 0.76 | KDM4E (0.50) | NPC1RAB9AMAPTKMT2ASMN1; SMN2 | |
| SCHEMBL8311457 | 0.76 | APP (0.43) | NPC1RAB9AMAPTKMT2ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL8311435 | 0.75 | PDE4B (0.30) | PDE4BPDE4DALOX5 | |
| Hydrochloric Acid SCHEMBL8312117 | 0.75 | RAB9A (0.42) | NPC1RAB9AMAPTKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0351856-B1 | Thiazolo[5,4-b]azepine compounds | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1999-09-15 | — | — | EP | disclosed |
| US-5300639-A | 2-oxo-3-carbonylamino-substituted azepine intermediates; lipoperoxide formation inhibitors | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1994-04-05 | — | — | US | disclosed |
| US-5118806-A | Enzyme inhibitor for lipoxygenase; useful for treating cancer, hepatic diseases, inflammation, cerebrovascular diseases | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1992-06-02 | — | — | US | disclosed |
| US-4956360-A | LIPOPEROXIDE INHIBITORS, ENZYME INHIBITORS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1990-09-11 | — | — | US | disclosed |