Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTNNB1 | P35222 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.51 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.49 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.49 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | ACP3 | P15309 | 1/20 | 0.46 |
| ▸ | AKT1 | P31749 | 2/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.46 |
| ▸ | PIM1 | P11309 | 1/20 | 0.46 |
| ▸ | PRKACA | P17612 | 1/20 | 0.46 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.46 |
| ▸ | GSK3A | P49840 | 1/20 | 0.46 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30887331 | 1.00 | CTNNB1 (0.55) | CTNNB1TDP1MTNR1ASLC1A3SLC1A2 | |
| SCHEMBL29397858 | 0.86 | CTNNB1 (0.59) | CTNNB1TDP1SLC1A3SLC1A2SLC1A1 | |
| SCHEMBL93516 | 0.86 | CTNNB1 (0.59) | CTNNB1TDP1SLC1A3SLC1A2SLC1A1 | |
| SCHEMBL29397866 | 0.86 | CTNNB1 (0.59) | CTNNB1TDP1SLC1A3SLC1A2SLC1A1 | |
| SCHEMBL93515 | 0.86 | CTNNB1 (0.59) | CTNNB1TDP1SLC1A3SLC1A2SLC1A1 | |
| SCHEMBL29482763 | 0.86 | CTNNB1 (0.59) | CTNNB1TDP1SLC1A3SLC1A2SLC1A1 | |
| SCHEMBL660499 | 0.86 | CTNNB1 (0.59) | CTNNB1TDP1SLC1A3SLC1A2SLC1A1 | |
| SCHEMBL1025267 | 0.86 | CTNNB1 (0.59) | CTNNB1TDP1SLC1A3SLC1A2SLC1A1 | |
| Hydrochloric Acid SCHEMBL30030000 | 0.85 | CTNNB1 (0.58) | CTNNB1TDP1SLC1A3SLC1A2SLC1A1 | |
| Hydrochloric Acid SCHEMBL5967395 | 0.85 | CTNNB1 (0.58) | CTNNB1TDP1SLC1A3SLC1A2SLC1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1874739-B1 | PHARMACEUTICALLY ACTIVE DIAZEPANES | NOVARTIS AG (CH) | 2010-05-26 | — | — | EP | disclosed |
| US-20080300237-A1 | Pharmaceutically Active Diazepanes | OBERHAUSER BERNDT | 2008-12-04 | — | — | US | disclosed |
| US-20080300237-A1 | Pharmaceutically Active Diazepanes | OBERHAUSER BERNDT | 2008-12-04 | — | — | US | disclosed |
| US-7419976-B2 | Diazepanes derivatives useful as IFA inhibitors | NOVARTIS AG (CH) | 2008-09-02 | — | — | US | disclosed |
| US-7419976-B2 | Diazepanes derivatives useful as IFA inhibitors | NOVARTIS AG (CH) | 2008-09-02 | — | — | US | disclosed |
| WO-2004065382-A1 | DIAZEPANES DERIVATIVES USEFUL AS LFA INHIBITORS | NOVARTIS AG (CH) | 2004-08-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080300237-A1 | Pharmaceutically Active Diazepanes | VCAM1, ICAM1, CD69 | CTNNB1 379/4885TDP1 2276/4885MTNR1A 1059/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.