SCHEMBL8316095

SCHEMBL8316095

CC1(C)Nc2ccccc2NC1=S

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BRPF1 P55201 1/20 0.36
CREBBP Q92793 1/20 0.36
ALDH1A1 P00352 9/20 0.35
TDP1 Q9NUW8 2/20 0.35
CYP3A4 P08684 1/20 0.35
HSD17B10 Q99714 1/20 0.35
HPGD P15428 3/20 0.35
ALOX12 P18054 2/20 0.35
MAPT P10636 3/20 0.35
BCHE P06276 1/20 0.34
ACHE P22303 1/20 0.34
KDM4E B2RXH2 4/20 0.34
MEN1 O00255 3/20 0.34
KMT2A Q03164 3/20 0.34
MAPK1 P28482 2/20 0.34
RECQL P46063 2/20 0.34
NPC1 O15118 1/20 0.34
HSP90AA1 P07900 1/20 0.34
THRB P10828 1/20 0.34
HK1 P19367 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30559954 0.74 CREBBP (0.35) CREBBPALDH1A1TDP1CYP3A4HSD17B10
SCHEMBL21624152 0.74 CREBBP (0.35) CREBBPALDH1A1TDP1CYP3A4HSD17B10
SCHEMBL29789747 0.73 PDK2 (0.52) BRPF1CREBBPALDH1A1TDP1HSD17B10
SCHEMBL757520 0.73 PDK2 (0.52) BRPF1CREBBPALDH1A1TDP1HSD17B10
SCHEMBL23648165 0.72 GSK3B (0.42) ALDH1A1HPGDMAPTKDM4ENPC1
SCHEMBL3642313 0.69 RAD52 (0.61) ALDH1A1TDP1CYP3A4HSD17B10HPGD
SCHEMBL30559943 0.69 CES1 (0.38) ALDH1A1RAD52
SCHEMBL21624055 0.69 CES1 (0.38) ALDH1A1RAD52
SCHEMBL22010250 0.69 PDK2 (0.46) ALDH1A1TDP1CYP3A4HSD17B10HPGD
SCHEMBL13729207 0.68 ALDH1A1 (0.51) ALDH1A1TDP1CYP3A4HSD17B10HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0536419-B1 TRICYCLIC TRIAZOLE DERIVATIVES, PRODUCTION AND USE THEREOF TORAY INDUSTRIES (JP) 1999-10-13 EP disclosed
EP-0609328-B1 PYRROLO-PYRIDAZINES WITH GASTRO-INTESTINAL PROTECTIVE ACTION BYK GULDEN LOMBERG CHEM FAB (DE) 1999-04-28 EP disclosed
US-5683998-A ANTIINFLAMMATORY AGENTS, ANTIALLERGENS, ANTIPAF AGENTS TORAY INDUSTRIES, INC. (JP) 1997-11-04 US disclosed
WO-1993008190-A1 PYRROLO-PYRIDAZINES WITH GASTRO-INTESTINAL PROTECTIVE ACTION BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) 1993-04-29 WO disclosed
EP-0536419-A1 TRICYCLIC TRIAZOLE DERIVATIVE, PRODUCTION THEREOF, AND USE THEREOF TORAY INDUSTRIES, INC. (JP) 1993-04-14 EP disclosed