SCHEMBL22010250

SCHEMBL22010250

CC1(C)Nc2ccccc21

nearest known ligand 0.46

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
PDK2 Q15119 1/20 0.46
PDK4 Q16654 1/20 0.46
HTR5A P47898 2/20 0.42
ATM Q13315 1/20 0.40
GAA P10253 1/20 0.40
ALDH1A1 P00352 3/20 0.39
CYP3A4 P08684 1/20 0.39
HSD17B10 Q99714 1/20 0.39
TDP1 Q9NUW8 1/20 0.39
BCHE P06276 1/20 0.39
ACHE P22303 1/20 0.39
RAD52 P43351 1/20 0.38
AKR1B1 P15121 4/20 0.38
KDM4E B2RXH2 1/20 0.38
MEN1 O00255 1/20 0.38
HPGD P15428 1/20 0.38
KMT2A Q03164 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.38
NOS2 P35228 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21662876 0.81 ALDH1A1 (0.47) PDK2PDK4HTR5AALDH1A1CYP3A4
SCHEMBL18403613 0.80 PDK2 (0.43) PDK2PDK4HTR5AATMGAA
SCHEMBL14501652 0.80 PDK2 (0.59) PDK2PDK4HTR5AGAAALDH1A1
SCHEMBL25365206 0.80 PDK2 (0.44) PDK2PDK4HTR5AGAAALDH1A1
SCHEMBL10061698 0.80 PDK2 (0.44) PDK2PDK4HTR5AGAAALDH1A1
SCHEMBL16369712 0.75 PDK2 (0.43) PDK2PDK4HTR5AGAAALDH1A1
SCHEMBL9791466 0.75 PDK2 (0.43) PDK2PDK4HTR5AATMGAA
SCHEMBL23260321 0.72 PDK2 (0.41) PDK2PDK4HTR5AATMALDH1A1
SCHEMBL15468271 0.72 PDK2 (0.41) PDK2PDK4HTR5AATMGAA
SCHEMBL24166676 0.72 ATM (0.42) PDK2PDK4HTR5AATMGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119403554-A Therapeutic or prophylactic agent for amyotrophic lateral sclerosis 东丽株式会社 2025-02-07 CN disclosed
CN-116648245-A Tetrahydroquinoline derivative and medical application thereof 东丽株式会社 2023-08-25 CN disclosed
EP-3880666-B1 COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY NOVARTIS AG (CH) 2023-06-28 EP disclosed
WO-2020102100-A9 COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY NOVARTIS AG (CH) 2022-01-06 WO disclosed
WO-2020102100-A1 COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY NOVARTIS INFLAMMASOME RESEARCH, INC. (US) 2020-05-22 WO disclosed
WO-2020102574-A1 THE COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY NOVARTIS INFLAMMASOME RESEARCH, INC. (US) 2020-05-22 WO disclosed