Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | GFER | P55789 | 1/20 | 0.57 |
| ▸ | EDNRA | P25101 | 11/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | EDNRB | P24530 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | NSD2 | O96028 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8537099 | 0.83 | EDNRA (0.59) | EDNRAKMT2AEDNRBKDM4ETSHR | |
| SCHEMBL10337882 | 0.82 | CA2 (0.51) | ALDH1A1LMNAGAAMAPTL3MBTL1 | |
| SCHEMBL6314447 | 0.81 | EDNRA (0.65) | ALDH1A1GAAMAPTL3MBTL1POLB | |
| SCHEMBL8311757 | 0.79 | EDNRA (0.72) | EDNRAKMT2AEDNRBKDM4ETSHR | |
| SCHEMBL13485942 | 0.78 | EDNRA (0.67) | EDNRAKMT2AKDM4ETSHRHSD17B10 | |
| SCHEMBL8316684 | 0.77 | EDNRA (0.54) | EDNRAKMT2AEDNRBKDM4ETSHR | |
| SCHEMBL8313029 | 0.76 | EDNRA (0.62) | EDNRAKDM4ETSHRHSD17B10NSD2 | |
| SCHEMBL10714752 | 0.75 | EDNRA (0.60) | EDNRAKDM4ETSHRHSD17B10NSD2 | |
| SCHEMBL8317647 | 0.75 | EDNRA (0.48) | EDNRAKMT2AEDNRBKDM4ETSHR | |
| SCHEMBL8313971 | 0.75 | EDNRA (0.48) | EDNRAKMT2AEDNRBKDM4ETSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733626-B1 | N-(Benzofuranazyl)-arylsulphonamides and their analogues useful as endothelin-receptor-antagonists | MERCK PATENT GMBH (DE) | 1999-01-13 | — | — | EP | disclosed |
| US-5726194-A | Endothelin receptor antagonists | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1998-03-10 | — | — | US | disclosed |
| EP-0733626-A1 | N-(Benzofuranazyl)-arylsulphonamides and their analogues useful as endothelin-receptor-antagonists | MERCK PATENT GmbH (DE) | 1996-09-25 | — | — | EP | disclosed |