Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 12/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | EDNRB | P24530 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | NSD2 | O96028 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8316684 | 0.86 | EDNRA (0.54) | EDNRAKDM4ETSHRHSD17B10EDNRB | |
| SCHEMBL8317647 | 0.83 | EDNRA (0.48) | EDNRAKDM4ETSHRHSD17B10EDNRB | |
| SCHEMBL8317669 | 0.81 | EDNRA (0.46) | EDNRAKDM4ETSHRHSD17B10EDNRB | |
| SCHEMBL8316284 | 0.75 | ALDH1A1 (0.59) | EDNRAKDM4ETSHRHSD17B10EDNRB | |
| SCHEMBL8311757 | 0.73 | EDNRA (0.72) | EDNRAKDM4ETSHRHSD17B10EDNRB | |
| SCHEMBL8313029 | 0.69 | EDNRA (0.62) | EDNRAKDM4ETSHRHSD17B10NSD2 | |
| SCHEMBL10337882 | 0.68 | CA2 (0.51) | EDNRAKDM4ETSHRHSD17B10EDNRB | |
| SCHEMBL8537099 | 0.68 | EDNRA (0.59) | EDNRAKDM4ETSHRHSD17B10EDNRB | |
| SCHEMBL8784615 | 0.67 | EDNRA (0.76) | EDNRAKDM4ETSHRHSD17B10EDNRB | |
| SCHEMBL7949496 | 0.67 | EDNRA (0.76) | EDNRAKDM4ETSHRHSD17B10EDNRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733626-B1 | N-(Benzofuranazyl)-arylsulphonamides and their analogues useful as endothelin-receptor-antagonists | MERCK PATENT GMBH (DE) | 1999-01-13 | — | — | EP | disclosed |
| US-5726194-A | Endothelin receptor antagonists | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1998-03-10 | — | — | US | disclosed |
| EP-0733626-A1 | N-(Benzofuranazyl)-arylsulphonamides and their analogues useful as endothelin-receptor-antagonists | MERCK PATENT GmbH (DE) | 1996-09-25 | — | — | EP | disclosed |