Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 18/20 | 0.56 |
| ▸ | HTR1B | P28222 | 12/20 | 0.56 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7449710 | 0.77 | HTR1D (0.53) | HTR1DHTR1BDRD2DRD4DRD3 | |
| SCHEMBL25521233 | 0.74 | HTR1D (0.53) | HTR1DHTR1B | |
| SCHEMBL31727562 | 0.74 | HTR1D (0.53) | HTR1DHTR1B | |
| SCHEMBL8886979 | 0.72 | HTR1D (1.00) | HTR1DHTR1BDRD2 | |
| SCHEMBL7434490 | 0.72 | HTR1D (0.81) | HTR1DHTR1BDRD2DRD4DRD3 | |
| SCHEMBL8887087 | 0.71 | HTR1D (0.47) | HTR1DHTR1B | |
| SCHEMBL9755468 | 0.66 | HTR1D (0.66) | HTR1DHTR1BDRD2 | |
| SCHEMBL95570 | 0.66 | — | — | |
| SCHEMBL11420212 | 0.66 | SAT1 (0.60) | — | |
| SCHEMBL8316283 | 0.65 | HTR1D (1.00) | HTR1DHTR1BDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0510068-B1 | NEW CENTRALLY ACTING 6,7,8,9-TETRAHYDRO-3H-BENZ(e)INDOLE HETEROCYCLICS | UPJOHN CO (US) | 1999-04-14 | — | — | EP | disclosed |
| US-5650427-A | ANTIDEPRESSANTS | THE UPJOHN COMPANY (US) | 1997-07-22 | — | — | US | disclosed |
| US-5461061-A | Antidepressants | WIKSTROM HAKAN V (NL) | 1995-10-24 | — | — | US | disclosed |
| US-5288748-A | Antidepressants | THE UPJOHN COMPANY (US) | 1994-02-22 | — | — | US | disclosed |