Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 16/20 | 1.00 |
| ▸ | HTR1B | P28222 | 12/20 | 1.00 |
| ▸ | HTR1A | P08908 | 2/20 | 0.59 |
| ▸ | DRD2 | P14416 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7434490 | 0.90 | HTR1D (0.81) | HTR1DHTR1BHTR1ADRD2 | |
| SCHEMBL8885860 | 0.75 | HTR1A (1.00) | HTR1DHTR1BHTR1ADRD2 | |
| SCHEMBL8315482 | 0.74 | HTR1D (1.00) | HTR1DHTR1B | |
| SCHEMBL5917114 | 0.72 | HTR1D (0.62) | HTR1DHTR1B | |
| SCHEMBL8316304 | 0.72 | HTR1D (0.56) | HTR1DHTR1BDRD2 | |
| SCHEMBL3201298 | 0.71 | HTR1D (1.00) | HTR1DHTR1B | |
| SCHEMBL8314164 | 0.71 | HTR1D (1.00) | HTR1DHTR1B | |
| SCHEMBL8314550 | 0.70 | DRD2 (0.60) | HTR1DHTR1BDRD2 | |
| SCHEMBL8630806 | 0.70 | DRD2 (0.60) | HTR1DHTR1BDRD2 | |
| SCHEMBL8631318 | 0.70 | DRD2 (0.60) | HTR1DHTR1BDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5650427-A | ANTIDEPRESSANTS | THE UPJOHN COMPANY (US) | 1997-07-22 | — | — | US | disclosed |
| US-5461061-A | Antidepressants | WIKSTROM HAKAN V (NL) | 1995-10-24 | — | — | US | disclosed |
| US-5288748-A | Antidepressants | THE UPJOHN COMPANY (US) | 1994-02-22 | — | — | US | disclosed |
| EP-0510068-A1 | NEW CENTRALLY ACTING 6,7,8,9-TETRAHYDRO-3H-BENZ(e)INDOLE HETEROCYCLICS | PHARMACIA & UPJOHN COMPANY (US) | 1992-10-28 | — | — | EP | disclosed |
| WO-1991011435-A2 | NEW CENTRALLY ACTING 6,7,8,9-TETRAHYDRO-3H-BENZ(e)INDOLE HETEROCYCLICS | THE UPJOHN COMPANY (US) | 1991-08-08 | — | — | WO | disclosed |