Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 8/20 | 0.63 |
| ▸ | ERBB2 | P04626 | 7/20 | 0.63 |
| ▸ | HPGD | P15428 | 1/20 | 0.63 |
| ▸ | HTT | P42858 | 1/20 | 0.63 |
| ▸ | EPHA2 | P29317 | 7/20 | 0.46 |
| ▸ | KDR | P35968 | 7/20 | 0.46 |
| ▸ | EPHB4 | P54760 | 7/20 | 0.46 |
| ▸ | BCL6 | P41182 | 2/20 | 0.46 |
| ▸ | BRAF | P15056 | 1/20 | 0.45 |
| ▸ | FLT1 | P17948 | 2/20 | 0.43 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.43 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8316373 | 1.00 | EGFR (0.63) | EGFRERBB2HPGDHTTEPHA2 | |
| SCHEMBL8316240 | 0.92 | EGFR (0.69) | EGFRERBB2HPGDHTTEPHA2 | |
| SCHEMBL8318083 | 0.92 | EGFR (0.76) | EGFRERBB2HPGDHTTKDR | |
| SCHEMBL8318086 | 0.92 | EGFR (0.76) | EGFRERBB2HPGDHTTKDR | |
| SCHEMBL8319178 | 0.88 | EGFR (0.57) | EGFRERBB2HPGDHTTBRAF | |
| SCHEMBL8319173 | 0.88 | EGFR (0.57) | EGFRERBB2HPGDHTTBRAF | |
| SCHEMBL8315620 | 0.87 | EGFR (0.64) | EGFRERBB2HPGDHTTBCL6 | |
| SCHEMBL8313702 | 0.87 | EGFR (0.64) | EGFRERBB2HPGDHTTBCL6 | |
| SCHEMBL8315344 | 0.87 | EGFR (0.64) | EGFRERBB2HPGDHTTBCL6 | |
| SCHEMBL8315348 | 0.87 | EGFR (0.64) | EGFRERBB2HPGDHTTBCL6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0779888-B1 | PYRIMIDO [5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | BOEHRINGER INGELHEIM PHARMA (DE) | 1999-04-28 | — | — | EP | disclosed |