Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 13/20 | 0.57 |
| ▸ | HPGD | P15428 | 2/20 | 0.57 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.51 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.51 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | FBP1 | P09467 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | GMNN | O75496 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | RAF1 | P04049 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8319173 | 1.00 | EGFR (0.57) | EGFRHPGDERBB2HTTCSNK2A2 | |
| SCHEMBL7142831 | 0.92 | EGFR (0.62) | EGFRHPGDERBB2HTTCSNK2A2 | |
| SCHEMBL8319095 | 0.90 | EGFR (0.64) | EGFRHPGDERBB2HTTCSNK2A1 | |
| SCHEMBL8319102 | 0.90 | EGFR (0.64) | EGFRHPGDERBB2HTTCSNK2A1 | |
| SCHEMBL8314964 | 0.89 | EGFR (0.65) | EGFRHPGDERBB2HTT | |
| SCHEMBL8314968 | 0.89 | EGFR (0.65) | EGFRHPGDERBB2HTT | |
| SCHEMBL8316366 | 0.88 | EGFR (0.63) | EGFRHPGDERBB2HTTCSNK2A1 | |
| SCHEMBL8316373 | 0.88 | EGFR (0.63) | EGFRHPGDERBB2HTTCSNK2A1 | |
| SCHEMBL8316922 | 0.87 | EGFR (0.58) | EGFRHPGDERBB2HTTCSNK2A2 | |
| SCHEMBL8316918 | 0.87 | EGFR (0.58) | EGFRHPGDERBB2HTTCSNK2A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0779888-B1 | PYRIMIDO [5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | BOEHRINGER INGELHEIM PHARMA (DE) | 1999-04-28 | — | — | EP | disclosed |