Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 17/20 | 1.00 |
| ▸ | HTR1B | P28222 | 13/20 | 1.00 |
| ▸ | DRD2 | P14416 | 2/20 | 0.57 |
| ▸ | DRD3 | P35462 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7442109 | 0.91 | HTR1D (0.84) | HTR1DHTR1BDRD2DRD3 | |
| SCHEMBL8315482 | 0.89 | HTR1D (1.00) | HTR1DHTR1B | |
| SCHEMBL8316283 | 0.84 | HTR1D (1.00) | HTR1DHTR1BDRD2 | |
| SCHEMBL7436234 | 0.83 | HTR1D (0.86) | HTR1DHTR1BDRD2DRD3 | |
| SCHEMBL8315256 | 0.82 | HTR1D (1.00) | HTR1DHTR1B | |
| SCHEMBL8318263 | 0.81 | HTR1D (1.00) | HTR1DHTR1BDRD2DRD3 | |
| SCHEMBL7434651 | 0.81 | HTR1D (0.83) | HTR1DHTR1BDRD2 | |
| SCHEMBL7442744 | 0.79 | HTR1D (0.81) | HTR1DHTR1B | |
| SCHEMBL8313410 | 0.78 | HTR1D (1.00) | HTR1DHTR1B | |
| SCHEMBL3736504 | 0.77 | DRD2 (0.79) | HTR1DHTR1BDRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0510068-B1 | NEW CENTRALLY ACTING 6,7,8,9-TETRAHYDRO-3H-BENZ(e)INDOLE HETEROCYCLICS | UPJOHN CO (US) | 1999-04-14 | — | — | EP | disclosed |
| US-5650427-A | ANTIDEPRESSANTS | THE UPJOHN COMPANY (US) | 1997-07-22 | — | — | US | disclosed |
| US-5461061-A | Antidepressants | WIKSTROM HAKAN V (NL) | 1995-10-24 | — | — | US | disclosed |
| US-5288748-A | Antidepressants | THE UPJOHN COMPANY (US) | 1994-02-22 | — | — | US | disclosed |
| EP-0510068-A1 | NEW CENTRALLY ACTING 6,7,8,9-TETRAHYDRO-3H-BENZ(e)INDOLE HETEROCYCLICS | PHARMACIA & UPJOHN COMPANY (US) | 1992-10-28 | — | — | EP | disclosed |
| WO-1991011435-A2 | NEW CENTRALLY ACTING 6,7,8,9-TETRAHYDRO-3H-BENZ(e)INDOLE HETEROCYCLICS | THE UPJOHN COMPANY (US) | 1991-08-08 | — | — | WO | disclosed |