Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 13/20 | 1.00 |
| ▸ | HTR1B | P28222 | 9/20 | 0.75 |
| ▸ | DRD2 | P14416 | 5/20 | 0.62 |
| ▸ | DRD4 | P21917 | 5/20 | 0.62 |
| ▸ | DRD3 | P35462 | 5/20 | 0.62 |
| ▸ | HTR1A | P08908 | 1/20 | 0.60 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.60 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.60 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.60 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.60 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.60 |
| ▸ | CNR1 | P21554 | 1/20 | 0.60 |
| ▸ | DRD1 | P21728 | 1/20 | 0.60 |
| ▸ | ACHE | P22303 | 1/20 | 0.60 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.60 |
| ▸ | HTR2A | P28223 | 1/20 | 0.60 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.60 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.60 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.60 |
| ▸ | HRH1 | P35367 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7439303 | 0.93 | HTR1D (0.87) | HTR1DHTR1BDRD2DRD4DRD3 | |
| SCHEMBL8315482 | 0.87 | HTR1D (1.00) | HTR1DHTR1B | |
| SCHEMBL8886099 | 0.81 | HTR1D (0.69) | HTR1DHTR1BDRD2HTR1A | |
| SCHEMBL8316440 | 0.81 | HTR1D (1.00) | HTR1DHTR1BDRD2DRD3 | |
| SCHEMBL15323709 | 0.80 | DRD2 (0.76) | HTR1DHTR1BDRD2DRD4DRD3 | |
| SCHEMBL8316936 | 0.80 | HTR1D (1.00) | HTR1DHTR1BHTR1A | |
| SCHEMBL8316283 | 0.79 | HTR1D (1.00) | HTR1DHTR1BDRD2HTR1A | |
| SCHEMBL2021033 | 0.79 | HTR1A (0.84) | HTR1DHTR1BDRD2DRD4DRD3 | |
| SCHEMBL2021960 | 0.79 | HTR1A (0.84) | HTR1DHTR1BDRD2DRD4DRD3 | |
| SCHEMBL2021032 | 0.79 | HTR1A (0.84) | HTR1DHTR1BDRD2DRD4DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0510068-B1 | NEW CENTRALLY ACTING 6,7,8,9-TETRAHYDRO-3H-BENZ(e)INDOLE HETEROCYCLICS | UPJOHN CO (US) | 1999-04-14 | — | — | EP | disclosed |
| US-5650427-A | ANTIDEPRESSANTS | THE UPJOHN COMPANY (US) | 1997-07-22 | — | — | US | disclosed |
| US-5461061-A | Antidepressants | WIKSTROM HAKAN V (NL) | 1995-10-24 | — | — | US | disclosed |
| US-5288748-A | Antidepressants | THE UPJOHN COMPANY (US) | 1994-02-22 | — | — | US | disclosed |