Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MLKL | Q8NB16 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | IDO1 | P14902 | 1/20 | 0.46 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | ALPL | P05186 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | METAP2 | P50579 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30601597 | 0.82 | MLKL (0.77) | MLKLSMN1; SMN2IDO1SLC2A1GAA | |
| SCHEMBL899731 | 0.82 | MLKL (0.77) | MLKLSMN1; SMN2IDO1SLC2A1GAA | |
| Hydrochloric Acid SCHEMBL28259019 | 0.81 | MLKL (0.74) | MLKLSMN1; SMN2IDO1SLC2A1GAA | |
| SCHEMBL3808816 | 0.79 | KMT2A (0.44) | MLKLSMN1; SMN2IDO1KDM4EALDH1A1 | |
| SCHEMBL18269214 | 0.75 | MLKL (0.54) | MLKLIDO1SLC2A1GAAKDM4E | |
| SCHEMBL18269212 | 0.75 | MLKL (0.57) | MLKLSMN1; SMN2IDO1SLC2A1GAA | |
| SCHEMBL18259723 | 0.75 | MLKL (0.69) | MLKLSMN1; SMN2IDO1SLC2A1GAA | |
| SCHEMBL1106417 | 0.74 | KDM4E (0.50) | MLKLSMN1; SMN2IDO1KDM4EALDH1A1 | |
| SCHEMBL21120174 | 0.73 | MLKL (0.51) | MLKLIDO1SLC2A1GAAKDM4E | |
| SCHEMBL18269213 | 0.73 | MLKL (0.55) | MLKLIDO1SLC2A1GAAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0590428-B1 | Azaquinoxalines, process for their preparation, and their use | HOECHST AG (DE) | 1999-12-15 | — | — | EP | disclosed |