Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 7/20 | 0.69 |
| ▸ | HTR2A | P28223 | 5/20 | 0.69 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.69 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.49 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.48 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.48 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.48 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | AHR | P35869 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | MGAM | O43451 | 1/20 | 0.46 |
| ▸ | SI | P14410 | 1/20 | 0.46 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29462 | 0.90 | HTR2A (0.59) | HTR2CHTR2AKCNH2ADRB2HTR1A | |
| SCHEMBL8726509 | 0.85 | LMNA (0.51) | HTR2CHTR2AKCNH2HTR1AAHR | |
| SCHEMBL7962369 | 0.82 | HTR2A (1.00) | HTR2CHTR2AKCNH2 | |
| SCHEMBL4077380 | 0.82 | HTR2C (0.51) | HTR2CHTR2AKCNH2ADRB2TLR9 | |
| SCHEMBL31060925 | 0.82 | HTR2A (1.00) | HTR2CHTR2AKCNH2 | |
| SCHEMBL18503045 | 0.81 | HTR2A (0.72) | HTR2CHTR2AKCNH2AHRGAA | |
| SCHEMBL6640509 | 0.81 | HTR2A (0.47) | HTR2CHTR2AKCNH2HTR1AAHR | |
| SCHEMBL31285825 | 0.80 | HTR2A (0.65) | HTR2CHTR2AKCNH2ADRB2TLR9 | |
| SCHEMBL22588189 | 0.80 | HTR2A (0.65) | HTR2CHTR2AKCNH2ADRB2TLR9 | |
| Hydrochloric Acid SCHEMBL11099668 | 0.79 | HTR2A (0.63) | HTR2CHTR2AKCNH2ADRB2TLR9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4100291-A | HYPOTENSIVE | ROUSSEL UCLAF (FR) | 1978-07-11 | — | — | US | claimed |
| US-9931347-B2 | Pharmaceutical compound | IOMET PHARMA LTD. (US) | 2018-04-03 | — | — | US | disclosed |
| US-20160367564-A1 | Pharmaceutical Compound | IOMET PHARMA LTD. (GB) | 2016-12-22 | — | — | US | disclosed |
| WO-2015082499-A2 | PHARMACEUTICAL COMPOUND | IOMET PHARMA LTD (GB) | 2015-06-11 | — | — | WO | disclosed |
| EP-1777223-A1 | Indole derivatives useful as histamine H3 antagonists | SCHERING CORPORATION (US) | 2007-04-25 | — | — | EP | disclosed |
| EP-0536419-B1 | TRICYCLIC TRIAZOLE DERIVATIVES, PRODUCTION AND USE THEREOF | TORAY INDUSTRIES (JP) | 1999-10-13 | — | — | EP | disclosed |
| US-5683998-A | ANTIINFLAMMATORY AGENTS, ANTIALLERGENS, ANTIPAF AGENTS | TORAY INDUSTRIES, INC. (JP) | 1997-11-04 | — | — | US | disclosed |
| EP-0536419-A1 | TRICYCLIC TRIAZOLE DERIVATIVE, PRODUCTION THEREOF, AND USE THEREOF | TORAY INDUSTRIES, INC. (JP) | 1993-04-14 | — | — | EP | disclosed |
| US-4100291-A | HYPOTENSIVE | ROUSSEL UCLAF (FR) | 1978-07-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160367564-A1 | Pharmaceutical Compound | TDO2, IDO1, IDO2 | HTR2C 133/4885HTR2A 511/4885KCNH2 3149/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.