Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RHEB | Q15382 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.40 |
| ▸ | TUBB | P07437 | 1/20 | 0.40 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.40 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.40 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.40 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.40 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.40 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.40 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.40 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.40 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.40 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.40 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.40 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9523299 | 0.94 | RHEB (0.41) | RHEBKDM4ELMNAL3MBTL1HTT | |
| SCHEMBL8314626 | 0.83 | TUBB4A (0.40) | KDM4ELMNAALDH1A1TUBB4ATUBB | |
| SCHEMBL8768199 | 0.82 | FABP6 (0.58) | RHEBKDM4ELMNAL3MBTL1HTT | |
| SCHEMBL6476374 | 0.81 | GAA (0.42) | RHEBKDM4ELMNAL3MBTL1HTT | |
| SCHEMBL10333608 | 0.80 | HSD17B10 (0.46) | RHEBLMNAHTTALDH1A1MAPT | |
| SCHEMBL23051806 | 0.79 | TDP1 (0.49) | RHEBKDM4ELMNAL3MBTL1HTT | |
| SCHEMBL10333780 | 0.78 | RHEB (0.38) | RHEBKDM4ELMNAL3MBTL1HTT | |
| SCHEMBL6217370 | 0.78 | HTT (0.64) | RHEBKDM4ELMNAL3MBTL1HTT | |
| SCHEMBL6217364 | 0.78 | KDM4E (0.50) | RHEBKDM4ELMNAL3MBTL1HTT | |
| SCHEMBL9261531 | 0.77 | TUBB4A (0.40) | KDM4ELMNAALDH1A1TUBB4ATUBB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0593463-B1 | DIALKOXY-PYRIDINYL-BENZIMIDAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR PHARMACEUTICAL USE | ASTRA AB (SE) | 1999-09-15 | — | — | EP | disclosed |
| US-5430042-A | Dialkoxy-pyridinyl-benzimidazole derivatives, process for their preparation and their pharmaceutical use | AKTIEBOLAGET ASTRA (SE) | 1995-07-04 | — | — | US | disclosed |
| EP-0593463-A1 | DIALKOXY-PYRIDINYL-BENZIMIDAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR PHARMACEUTICAL USE | AKTIEBOLAGET ASTRA (SE) | 1994-04-27 | — | — | EP | disclosed |
| EP-0129409-B1 | Thiazolo - and thiazinobenzimidazoles | WYETH JOHN & BROTHER LTD (GB) | 1993-10-27 | — | — | EP | disclosed |
| WO-1991019712-A1 | DIALKOXY-PYRIDINYL-BENZIMIDAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR PHARMACEUTICAL USE | AKTIEBOLAGET ASTRA (SE) | 1991-12-26 | — | — | WO | disclosed |
| US-4873237-A | ANTIULCER AGENTS | JOHN WYETH & BROTHER LIMITED (GB) | 1989-10-10 | — | — | US | disclosed |
| EP-0129409-A2 | Thiazolo - and thiazinobenzimidazoles | JOHN WYETH & BROTHER LIMITED (GB) | 1984-12-27 | — | — | EP | disclosed |