Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 12/20 | 0.64 |
| ▸ | IRAK4 | Q9NWZ3 | 7/20 | 0.54 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | BRAF | P15056 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8316660 | 1.00 | EGFR (0.64) | EGFRIRAK4ERBB2HPGDHTT | |
| SCHEMBL8319428 | 0.93 | EGFR (0.73) | EGFRERBB2HPGDHTTBRAF | |
| SCHEMBL8315923 | 0.90 | EGFR (0.65) | EGFRIRAK4ERBB2HPGDHTT | |
| SCHEMBL8316363 | 0.90 | EGFR (0.57) | EGFRIRAK4ERBB2HPGDHTT | |
| SCHEMBL8315919 | 0.90 | EGFR (0.65) | EGFRIRAK4ERBB2HPGDHTT | |
| SCHEMBL8316360 | 0.90 | EGFR (0.57) | EGFRIRAK4ERBB2HPGDHTT | |
| SCHEMBL8318072 | 0.89 | EGFR (0.71) | EGFRERBB2HPGDHTTBRAF | |
| SCHEMBL8318282 | 0.89 | EGFR (0.71) | EGFRERBB2HPGDHTTBRAF | |
| SCHEMBL8313624 | 0.88 | EGFR (0.67) | EGFRERBB2HPGDHTTBRAF | |
| SCHEMBL8313632 | 0.88 | EGFR (0.67) | EGFRERBB2HPGDHTTBRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0779888-B1 | PYRIMIDO [5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | BOEHRINGER INGELHEIM PHARMA (DE) | 1999-04-28 | — | — | EP | disclosed |