Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 14/20 | 0.71 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | SYK | P43405 | 4/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.50 |
| ▸ | MAPK3 | P27361 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.50 |
| ▸ | BRAF | P15056 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8318072 | 0.98 | EGFR (0.71) | EGFRERBB2HPGDHTTSYK | |
| SCHEMBL8319537 | 0.97 | EGFR (0.69) | EGFRERBB2HPGDHTTSYK | |
| SCHEMBL8319428 | 0.96 | EGFR (0.73) | EGFRERBB2HPGDHTTSYK | |
| SCHEMBL8313507 | 0.92 | EGFR (0.63) | EGFRERBB2HPGDHTTSYK | |
| SCHEMBL8319114 | 0.91 | EGFR (0.67) | EGFRERBB2HPGDHTTSYK | |
| SCHEMBL8316255 | 0.91 | EGFR (0.67) | EGFRERBB2HPGDHTTSYK | |
| SCHEMBL8313624 | 0.91 | EGFR (0.67) | EGFRERBB2HPGDHTTSYK | |
| SCHEMBL8313632 | 0.91 | EGFR (0.67) | EGFRERBB2HPGDHTTSYK | |
| SCHEMBL8319108 | 0.91 | EGFR (0.67) | EGFRERBB2HPGDHTTSYK | |
| SCHEMBL8322339 | 0.91 | EGFR (0.67) | EGFRERBB2HPGDHTTSYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0779888-B1 | PYRIMIDO [5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | BOEHRINGER INGELHEIM PHARMA (DE) | 1999-04-28 | — | — | EP | disclosed |