Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | CA12 | O43570 | 3/20 | 0.45 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.45 |
| ▸ | AKT1 | P31749 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | MGAM | O43451 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | SI | P14410 | 1/20 | 0.39 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.39 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1258535 | 0.81 | TSHR (0.55) | TSHRLMNAALDH1A1CA12CA14 | |
| SCHEMBL8792788 | 0.77 | AKT1 (0.59) | TSHRLMNAALDH1A1CA12CA14 | |
| SCHEMBL8792782 | 0.77 | AKT1 (0.59) | TSHRLMNAALDH1A1CA12CA14 | |
| SCHEMBL9188658 | 0.77 | TSHR (0.63) | TSHRLMNAALDH1A1CA12CA14 | |
| SCHEMBL2401509 | 0.77 | TSHR (0.63) | TSHRLMNAALDH1A1CA12CA14 | |
| SCHEMBL17165778 | 0.77 | TSHR (0.63) | TSHRLMNAALDH1A1CA12CA14 | |
| SCHEMBL2401513 | 0.77 | TSHR (0.63) | TSHRLMNAALDH1A1CA12CA14 | |
| SCHEMBL6945786 | 0.75 | — | — | |
| SCHEMBL242764 | 0.75 | — | — | |
| Dimethyl Succinate SCHEMBL28648367 | 0.75 | TSHR (0.68) | TSHRLMNAALDH1A1CA12CA14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0609328-B1 | PYRROLO-PYRIDAZINES WITH GASTRO-INTESTINAL PROTECTIVE ACTION | BYK GULDEN LOMBERG CHEM FAB (DE) | 1999-04-28 | — | — | EP | claimed |