Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Dimethyl Succinate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 6/20 | 0.68 |
| ▸ | HCAR2 | Q8TDS4 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.47 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.43 |
| ▸ | AKT1 | P31749 | 1/20 | 0.43 |
| ▸ | MGAM | O43451 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | SI | P14410 | 1/20 | 0.42 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL27875761 | 0.93 | TSHR (0.59) | TSHRHCAR2LMNAALDH1A1KDM4E | |
| Maleic Acid SCHEMBL28297793 | 0.84 | TSHR (0.72) | TSHRHCAR2LMNAALDH1A1HSD17B10 | |
| Dimethyl Succinate SCHEMBL28054469 | 0.83 | TSHR (1.00) | TSHRLMNAALDH1A1KDM4EHSD17B10 | |
| Dimethyl Succinate SCHEMBL10213 | 0.83 | TSHR (1.00) | TSHRLMNAALDH1A1KDM4EHSD17B10 | |
| Dimethyl Succinate SCHEMBL27918747 | 0.82 | TSHR (0.65) | TSHRLMNAALDH1A1KDM4EHSD17B10 | |
| SCHEMBL8792788 | 0.81 | AKT1 (0.59) | TSHRHCAR2LMNAALDH1A1KDM4E | |
| SCHEMBL8792782 | 0.81 | AKT1 (0.59) | TSHRHCAR2LMNAALDH1A1KDM4E | |
| SCHEMBL22043406 | 0.81 | ALDH1A1 (0.50) | TSHRHCAR2LMNAALDH1A1CA12 | |
| Dimethyl Succinate SCHEMBL28197319 | 0.80 | TSHR (0.81) | TSHRLMNAALDH1A1KDM4EHSD17B10 | |
| SCHEMBL29796261 | 0.80 | POLB (0.55) | TSHRHCAR2LMNAALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113649021-B | Preparation method of copper hydrogenation catalyst | 濮阳圣恺环保新材料科技股份有限公司 | 2023-12-01 | — | — | CN | claimed |
| CN-113649021-B | Preparation method of copper hydrogenation catalyst | 濮阳圣恺环保新材料科技股份有限公司 | 2023-12-01 | — | — | CN | disclosed |
| CN-113649021-B | Preparation method of copper hydrogenation catalyst | 濮阳圣恺环保新材料科技股份有限公司 | 2023-12-01 | — | — | CN | disclosed |
| CN-113649021-A | Preparation method of copper hydrogenation catalyst | 濮阳圣恺环保新材料科技股份有限公司 | 2021-11-16 | — | — | CN | disclosed |
| CN-113649021-A | Preparation method of copper hydrogenation catalyst | 濮阳圣恺环保新材料科技股份有限公司 | 2021-11-16 | — | — | CN | disclosed |
| CN-113600186-A | Preparation method of copper-based hydrogenation catalyst with high mechanical strength | 濮阳圣恺环保新材料科技股份有限公司 | 2021-11-05 | — | — | CN | disclosed |
| CN-113600186-A | Preparation method of copper-based hydrogenation catalyst with high mechanical strength | 濮阳圣恺环保新材料科技股份有限公司 | 2021-11-05 | — | — | CN | disclosed |