Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 5/20 | 0.42 |
| ▸ | MPL | P40238 | 2/20 | 0.32 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.31 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL102339 | 0.74 | KIF11 (0.41) | KIF11MPLKDM1AGLAPOLB | |
| SCHEMBL2749699 | 0.73 | KIF11 (0.44) | KIF11MPLKDM1AGLAPOLB | |
| SCHEMBL2776951 | 0.72 | STIM1 (0.42) | KIF11GAA | |
| SCHEMBL7450010 | 0.71 | POLB (0.46) | KIF11KDM1AGLAPOLBGAA | |
| SCHEMBL1561647 | 0.71 | TAAR1 (0.36) | KIF11GAATSHR | |
| SCHEMBL634584 | 0.69 | ALDH1A1 (0.36) | — | |
| SCHEMBL9219920 | 0.69 | KIF11 (0.44) | KIF11MPLKDM1AGLAPOLB | |
| SCHEMBL31522139 | 0.67 | EPAS1 (0.39) | KIF11GLAPOLBGAATSHR | |
| SCHEMBL21490256 | 0.67 | KIF11 (0.39) | KIF11NOTUM | |
| SCHEMBL25296233 | 0.67 | MAP3K12 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0929533-A1 | 4,4-DISUBSTITUTED-1,4-DIHYDRO-2H-3,1-BENZOXAZIN-2-ONES USEFUL AS HIV REVERSE TRANSCRIPTASE INHIBITORS AND INTERMEDIATES AND PROCESSES FOR MAKING THE SAME | Du Pont Pharmaceuticals Company (US) | 1999-07-21 | — | — | EP | disclosed |
| WO-1998014436-A1 | 4,4-DISUBSTITUTED-1,4-DIHYDRO-2H-3,1-BENZOXAZIN-2-ONES USEFUL AS HIV REVERSE TRANSCRIPTASE INHIBITORS AND INTERMEDIATES AND PROCESSES FOR MAKING THE SAME | DUPONT PHARMACEUTICALS COMPANY (US) | 1998-04-09 | — | — | WO | disclosed |