Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.53 |
| ▸ | TACR1 | P25103 | 1/20 | 0.46 |
| ▸ | HTR6 | P50406 | 2/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | SSTR1 | P30872 | 1/20 | 0.43 |
| ▸ | SSTR2 | P30874 | 1/20 | 0.43 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.43 |
| ▸ | SSTR3 | P32745 | 1/20 | 0.43 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 2/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CDK4 | P11802 | 2/20 | 0.41 |
| ▸ | CCND1 | P24385 | 2/20 | 0.41 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.41 |
| ▸ | PRKACA | P17612 | 1/20 | 0.41 |
| ▸ | PRKACG | P22612 | 1/20 | 0.41 |
| ▸ | PRKACB | P22694 | 1/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9000991 | 0.82 | CDK4 (0.44) | HTR6CDK4CCND1CCNE2PRKACA | |
| SCHEMBL9375258 | 0.80 | SIRT2 (0.49) | SIRT2TACR1HTR6ATMSSTR1 | |
| SCHEMBL8314260 | 0.79 | SIRT2 (0.69) | SIRT2TACR1CDK4CCND1CCNE2 | |
| SCHEMBL8315890 | 0.77 | NQO1 (0.53) | TACR1HTR6ATMSMN1; SMN2CA9 | |
| SCHEMBL8313886 | 0.75 | PRKACA (0.61) | SIRT2TACR1SMN1; SMN2CDK4CCND1 | |
| SCHEMBL18669003 | 0.72 | CA9 (0.61) | ATMSMN1; SMN2CA9CA1CA2 | |
| SCHEMBL8317402 | 0.71 | SIRT2 (0.63) | SIRT2HTR6CDK4CCND1CCNE2 | |
| SCHEMBL7193605 | 0.70 | SIRT2 (1.00) | SIRT2TACR1CDK4CCND1CCNE2 | |
| SCHEMBL8317087 | 0.70 | ATM (0.58) | ATMSMN1; SMN2CA9CA1CA2 | |
| SCHEMBL8316640 | 0.67 | SIRT2 (0.68) | SIRT2SMN1; SMN2CA9CA2CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0630242-B1 | FURTHER INDOLE DERIVATIVES WITH ANTIVIRAL ACTIVITY | WELLCOME FOUND (GB) | 1999-01-20 | — | — | EP | disclosed |
| US-5547976-A | VIRICIDES, HERPES VIRUS, CYTOMEGALOVIRUS; CARDIOVASCULAR DISORDERS | BURROUGHS WELLCOME CO. (US) | 1996-08-20 | — | — | US | disclosed |
| EP-0630242-A1 | FURTHER INDOLE DERIVATIVES WITH ANTIVIRAL ACTIVITY | THE WELLCOME FOUNDATION LIMITED (GB) | 1994-12-28 | — | — | EP | disclosed |
| WO-1993018766-A1 | FURTHER INDOLE DERIVATIVES WITH ANTIVIRAL ACTIVITY | THE WELLCOME FOUNDATION LIMITED (GB) | 1993-09-30 | — | — | WO | disclosed |