Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | BCL2 | P10415 | 1/20 | 0.53 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | GFER | P55789 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | PKLR | P30613 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | ELANE | P08246 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | CASP3 | P42574 | 1/20 | 0.44 |
| ▸ | CASP4 | P49662 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7193605 | 0.82 | SIRT2 (1.00) | SIRT2HTTSIRT1KMT2AMEN1 | |
| SCHEMBL31687464 | 0.78 | ALDH1A1 (0.73) | ALDH1A1HPGDHTTKMT2AMEN1 | |
| SCHEMBL2049541 | 0.78 | ALDH1A1 (0.73) | ALDH1A1HPGDHTTKMT2AMEN1 | |
| SCHEMBL28006388 | 0.76 | RAB9A (0.54) | SIRT2ALDH1A1HPGDHTTBCL2 | |
| SCHEMBL8318378 | 0.76 | NQO1 (0.68) | ALDH1A1HPGDHTTKMT2AMEN1 | |
| SCHEMBL8322554 | 0.74 | SIRT2 (0.74) | SIRT2SIRT1KMT2AMEN1GAA | |
| SCHEMBL23649349 | 0.74 | ELANE (0.60) | ALDH1A1BCL2KMT2AMEN1GAA | |
| SCHEMBL29824887 | 0.74 | ELANE (0.60) | ALDH1A1BCL2KMT2AMEN1GAA | |
| SCHEMBL8314260 | 0.74 | SIRT2 (0.69) | SIRT2SIRT1 | |
| SCHEMBL2952856 | 0.73 | PKM (0.64) | ALDH1A1BCL2KMT2AMEN1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0630242-B1 | FURTHER INDOLE DERIVATIVES WITH ANTIVIRAL ACTIVITY | WELLCOME FOUND (GB) | 1999-01-20 | — | — | EP | disclosed |
| US-5547976-A | VIRICIDES, HERPES VIRUS, CYTOMEGALOVIRUS; CARDIOVASCULAR DISORDERS | BURROUGHS WELLCOME CO. (US) | 1996-08-20 | — | — | US | disclosed |
| EP-0630242-A1 | FURTHER INDOLE DERIVATIVES WITH ANTIVIRAL ACTIVITY | THE WELLCOME FOUNDATION LIMITED (GB) | 1994-12-28 | — | — | EP | disclosed |
| WO-1993018766-A1 | FURTHER INDOLE DERIVATIVES WITH ANTIVIRAL ACTIVITY | THE WELLCOME FOUNDATION LIMITED (GB) | 1993-09-30 | — | — | WO | disclosed |