Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 19/20 | 0.53 |
| ▸ | FADS1 | O60427 | 1/20 | 0.46 |
| ▸ | LCK | P06239 | 1/20 | 0.46 |
| ▸ | FBP1 | P09467 | 1/20 | 0.45 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8316868 | 0.92 | EGFR (0.53) | EGFRFADS1LCKFBP1ERBB2 | |
| SCHEMBL8315733 | 0.89 | EGFR (0.69) | EGFRERBB2 | |
| SCHEMBL8316788 | 0.88 | EGFR (0.58) | EGFRFADS1LCKFBP1ERBB2 | |
| SCHEMBL8319419 | 0.88 | EGFR (0.70) | EGFR | |
| SCHEMBL8318470 | 0.87 | EGFR (0.48) | EGFRERBB2 | |
| SCHEMBL8318372 | 0.86 | EGFR (0.59) | EGFRFBP1ERBB2 | |
| SCHEMBL8318939 | 0.85 | EGFR (0.51) | EGFRLCKFBP1ERBB2 | |
| SCHEMBL8313472 | 0.84 | EGFR (0.53) | EGFRFADS1LCKFBP1 | |
| SCHEMBL8315550 | 0.84 | ABCG2 (0.51) | EGFR | |
| SCHEMBL8314176 | 0.81 | EGFR (0.53) | EGFRFADS1LCKERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0779888-B1 | PYRIMIDO [5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | BOEHRINGER INGELHEIM PHARMA (DE) | 1999-04-28 | — | — | EP | disclosed |