Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 15/20 | 0.51 |
| ▸ | FBP1 | P09467 | 2/20 | 0.48 |
| ▸ | GAK | O14976 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.46 |
| ▸ | ERBB4 | Q15303 | 2/20 | 0.46 |
| ▸ | PLK4 | O00444 | 1/20 | 0.46 |
| ▸ | CIT | O14578 | 1/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.46 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.46 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.46 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.46 |
| ▸ | BUB1 | O43683 | 1/20 | 0.46 |
| ▸ | KDM1A | O60341 | 1/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.46 |
| ▸ | STK17B | O94768 | 1/20 | 0.46 |
| ▸ | STK10 | O94804 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8314305 | 0.93 | EGFR (0.52) | EGFRFBP1GAKALDH1A1MAPT | |
| SCHEMBL8317979 | 0.89 | EGFR (0.55) | EGFRFBP1GAKALDH1A1MAPT | |
| SCHEMBL8315733 | 0.86 | EGFR (0.69) | EGFRERBB2 | |
| SCHEMBL8319419 | 0.85 | EGFR (0.70) | EGFR | |
| SCHEMBL8317141 | 0.85 | EGFR (0.53) | EGFRFBP1ERBB2LCK | |
| SCHEMBL8317531 | 0.85 | EGFR (0.51) | EGFRFBP1GAKALDH1A1MAPT | |
| SCHEMBL8316734 | 0.83 | EGFR (0.55) | EGFRFBP1GAKALDH1A1MAPT | |
| SCHEMBL8316897 | 0.82 | EGFR (0.50) | EGFRFBP1GAKALDH1A1MAPT | |
| SCHEMBL8315550 | 0.81 | ABCG2 (0.51) | EGFRALDH1A1MAPTRAF1BRAF | |
| SCHEMBL8318849 | 0.81 | EGFR (0.55) | EGFRFBP1GAKALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0779888-B1 | PYRIMIDO [5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | BOEHRINGER INGELHEIM PHARMA (DE) | 1999-04-28 | — | — | EP | disclosed |