Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 15/20 | 0.49 |
| ▸ | ERBB2 | P04626 | 4/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6990190 | 0.90 | EGFR (0.59) | EGFRERBB2HPGDHTTMAPT | |
| SCHEMBL8318233 | 0.86 | EGFR (0.47) | EGFRERBB2HPGDHTTMAPT | |
| SCHEMBL6992072 | 0.86 | EGFR (0.44) | EGFRERBB2HPGDHTTMAPT | |
| SCHEMBL8315330 | 0.85 | EGFR (0.57) | EGFRERBB2HPGDMAPT | |
| SCHEMBL7090432 | 0.84 | EGFR (0.56) | EGFRERBB2 | |
| SCHEMBL6997375 | 0.84 | EGFR (0.47) | EGFRERBB2HPGDHTTMAPT | |
| SCHEMBL6989835 | 0.83 | EGFR (0.57) | EGFRERBB2 | |
| SCHEMBL6417047 | 0.82 | EGFR (0.66) | EGFRERBB2HTTDYRK1ADYRK1B | |
| SCHEMBL6992624 | 0.81 | EGFR (0.43) | EGFRERBB2HPGDHTTMAPT | |
| SCHEMBL6993872 | 0.81 | EGFR (0.69) | EGFRHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0779888-B1 | PYRIMIDO [5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | BOEHRINGER INGELHEIM PHARMA (DE) | 1999-04-28 | — | — | EP | disclosed |
| EP-0779888-A1 | PYRIMIDO [5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | Dr. Karl Thomae GmbH (DE) | 1997-06-25 | — | — | EP | disclosed |
| WO-1996007657-A1 | PYRIMIDO[5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | DR. KARL THOMAE GMBH (DE) | 1996-03-14 | — | — | WO | disclosed |