Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 12/20 | 0.47 |
| ▸ | ARNT | P27540 | 1/20 | 0.43 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.43 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | CRHBP | P24387 | 1/20 | 0.41 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.41 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8319085 | 0.88 | EGFR (0.44) | EGFRABCG2CA1CA2CA7 | |
| SCHEMBL8317145 | 0.86 | EGFR (0.49) | EGFRERBB2HPGDHTTMAPT | |
| SCHEMBL8318382 | 0.83 | EGFR (0.47) | EGFRARNTEPAS1ABCG2BRD4 | |
| SCHEMBL6994362 | 0.82 | ABCG2 (0.56) | EGFRABCG2 | |
| SCHEMBL6990190 | 0.81 | EGFR (0.59) | EGFRERBB2HPGDHTTMAPT | |
| SCHEMBL8315330 | 0.79 | EGFR (0.57) | EGFRERBB2HPGDLMNAMAPT | |
| SCHEMBL6992072 | 0.78 | EGFR (0.44) | EGFRERBB2HPGDHTTMAPT | |
| SCHEMBL6997375 | 0.78 | EGFR (0.47) | EGFRERBB2HPGDHTTMAPT | |
| SCHEMBL6992428 | 0.77 | GSK3A (0.55) | EGFRABCG2BRD4ERBB2HPGD | |
| SCHEMBL6992432 | 0.77 | GSK3A (0.55) | EGFRABCG2BRD4ERBB2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0779888-B1 | PYRIMIDO [5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | BOEHRINGER INGELHEIM PHARMA (DE) | 1999-04-28 | — | — | EP | disclosed |