Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 19/20 | 0.57 |
| ▸ | FADS1 | O60427 | 2/20 | 0.51 |
| ▸ | LCK | P06239 | 1/20 | 0.50 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | GMNN | O75496 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | ABL1 | P00519 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | RAF1 | P04049 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | FBP1 | P09467 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | SRC | P12931 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6993872 | 0.87 | EGFR (0.69) | EGFRMAPK1HIF1A | |
| SCHEMBL8320084 | 0.86 | EGFR (0.70) | EGFRERBB2MEN1KMT2AMKNK1 | |
| SCHEMBL8314880 | 0.86 | EGFR (0.53) | EGFRLCKABL1FBP1ABL2 | |
| SCHEMBL6417047 | 0.86 | EGFR (0.66) | EGFRERBB2KDM4EMEN1ABL1 | |
| SCHEMBL8317145 | 0.85 | EGFR (0.49) | EGFRERBB2MAPTHPGD | |
| SCHEMBL8315829 | 0.84 | EGFR (0.51) | EGFR | |
| SCHEMBL8320237 | 0.84 | EGFR (0.55) | EGFRMEN1LMNASRCKMT2A | |
| SCHEMBL6990190 | 0.84 | EGFR (0.59) | EGFRERBB2MEN1FBP1MAPT | |
| SCHEMBL8318188 | 0.84 | EGFR (0.55) | EGFR | |
| SCHEMBL6990835 | 0.84 | EGFR (0.50) | EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0779888-B1 | PYRIMIDO [5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | BOEHRINGER INGELHEIM PHARMA (DE) | 1999-04-28 | — | — | EP | disclosed |