Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 1/20 | 0.35 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.32 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.32 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.32 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.32 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.32 |
| ▸ | HTR5A | P47898 | 1/20 | 0.31 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.31 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.31 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8315757 | 0.78 | CA12 (0.36) | KDM4ERECQLDPP8DPP9DPP7 | |
| SCHEMBL2603740 | 0.76 | KDM4E (0.47) | KDM4ERECQLOPRL1OPRM1KCNH2 | |
| SCHEMBL8318662 | 0.71 | DPP8 (0.36) | KDM4ERECQLDPP8DPP9DPP7 | |
| SCHEMBL22326637 | 0.67 | HTR5A (0.38) | MMP13HTR5ANOTUM | |
| SCHEMBL31424385 | 0.67 | HTR5A (0.38) | MMP13HTR5ANOTUM | |
| SCHEMBL21257762 | 0.65 | HTT (0.46) | KDM4ECDK5CDK5R1HTR5AOPRM1 | |
| SCHEMBL6490844 | 0.63 | KDM4E (0.35) | KDM4ERECQLHTR5A | |
| SCHEMBL8314425 | 0.63 | KDM4E (0.40) | KDM4ERECQLDPP8DPP9DPP7 | |
| SCHEMBL14253616 | 0.63 | MMP13 (0.38) | KDM4ERECQLMMP13CDK5CDK5R1 | |
| SCHEMBL4614120 | 0.62 | MMP13 (0.40) | KDM4ERECQLMMP13CDK5CDK5R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5929072-A | TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS | ELI LILLY AND COMPANY LIMITED (GB) | 1999-07-27 | — | — | US | disclosed |
| EP-0897921-A1 | Benzothiadiazinyl-indole derivatives and their use as serotonin receptor ligands | ELI LILLY AND COMPANY LIMITED (GB) | 1999-02-24 | — | — | EP | disclosed |