Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 7/20 | 0.43 |
| ▸ | BRD2 | P25440 | 2/20 | 0.43 |
| ▸ | BRD3 | Q15059 | 2/20 | 0.43 |
| ▸ | OXTR | P30559 | 2/20 | 0.39 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.39 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8319738 | 0.93 | BRD4 (0.44) | BRD4BRD2BRD3HDAC3HDAC4 | |
| SCHEMBL8318824 | 0.92 | BRD4 (0.45) | BRD4BRD2BRD3OXTRAVPR2 | |
| SCHEMBL8319404 | 0.92 | BRD4 (0.47) | BRD4BRD2BRD3OXTRAVPR2 | |
| SCHEMBL8320603 | 0.91 | BRD4 (0.48) | BRD4BRD2BRD3HTTLMNA | |
| SCHEMBL8322984 | 0.87 | BRD4 (0.51) | BRD4BRD2BRD3MEN1KMT2A | |
| SCHEMBL8318456 | 0.83 | BRD4 (0.55) | BRD4BRD2BRD3LMNAHDAC3 | |
| SCHEMBL8316386 | 0.83 | BRD4 (0.44) | BRD4BRD2BRD3MEN1KMT2A | |
| SCHEMBL8318078 | 0.82 | BRD4 (0.44) | BRD4BRD2BRD3OXTRHTT | |
| SCHEMBL8319389 | 0.82 | BRD4 (0.46) | BRD4BRD2BRD3LMNAHDAC1 | |
| SCHEMBL8318050 | 0.82 | BRD4 (0.63) | BRD4BRD2BRD3LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934940-A1 | CYTOKINE PRODUCTION INHIBITORS, TRIAZEPINE COMPOUNDS, AND INTERMEDIATES THEREOF | Japan Tobacco Inc. (JP) | 1999-08-11 | — | — | EP | claimed |
| EP-0934940-A1 | CYTOKINE PRODUCTION INHIBITORS, TRIAZEPINE COMPOUNDS, AND INTERMEDIATES THEREOF | Japan Tobacco Inc. (JP) | 1999-08-11 | — | — | EP | disclosed |